Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11529908 | 0.83 | TSHR (0.43) | TSHRPPARDLMNAMAPTMAPK1 | |
| SCHEMBL15438836 | 0.83 | TSHR (0.43) | TSHRPPARDMAPTMAPK1TP53 | |
| SCHEMBL15438445 | 0.80 | TSHR (0.45) | TSHRPPARDMAPTMAPK1TP53 | |
| SCHEMBL11427698 | 0.80 | TSHR (0.40) | TSHRPPARDMAPTMAPK1TP53 | |
| SCHEMBL17937994 | 0.79 | TSHR (0.39) | TSHRPPARDMAPTMAPK1TP53 | |
| SCHEMBL15438370 | 0.77 | TSHR (0.38) | TSHRPPARDLMNAMAPTMAPK1 | |
| SCHEMBL15438624 | 0.76 | TSHR (0.36) | TSHRPPARDMAPTMAPK1TDP1 | |
| SCHEMBL15438284 | 0.76 | TSHR (0.41) | TSHRPPARDMAPTMAPK1 | |
| SCHEMBL15438017 | 0.76 | TSHR (0.41) | TSHRPPARDMAPTMAPK1 | |
| SCHEMBL15438637 | 0.76 | TSHR (0.36) | TSHRPPARDLMNAMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4196229-A | NITRILES, ESTERS, AMIDES, SULFONES, AND KETONES | SANDOZ LTD. (CH) | 1980-04-01 | — | — | US | disclosed |
| US-4108887-A | Divinyl stilbenes as optical brighteners | SANDOZ LTD. (CH) | 1978-08-22 | — | — | US | disclosed |