Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 3/20 | 0.39 |
| ▸ | GCGR | P47871 | 5/20 | 0.37 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | VIPR2 | P41587 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11472733 | 0.92 | MAPT (0.43) | MAP3K14GCGRCYP26A1ALOX5PTGS1 | |
| SCHEMBL11596474 | 0.92 | MAP3K14 (0.41) | MAP3K14GCGRCYP26A1MEN1KMT2A | |
| SCHEMBL11454347 | 0.87 | MAP3K14 (0.41) | MAP3K14GCGRCYP26A1TP53GAA | |
| SCHEMBL11463589 | 0.87 | MAP3K14 (0.43) | MAP3K14GCGRCYP26A1MEN1KMT2A | |
| SCHEMBL11459956 | 0.84 | MAP3K14 (0.41) | MAP3K14GCGRCYP26A1MEN1KMT2A | |
| SCHEMBL11452706 | 0.83 | MAP3K14 (0.40) | MAP3K14CYP26A1GAAMAPTMEN1 | |
| SCHEMBL11454020 | 0.83 | MAP3K14 (0.40) | MAP3K14GCGRCYP26A1MEN1KMT2A | |
| SCHEMBL11465090 | 0.82 | MAP3K14 (0.41) | MAP3K14GCGRTP53GAAMAPT | |
| SCHEMBL11461089 | 0.82 | MAPT (0.45) | MAP3K14GCGRGAAMAPTMEN1 | |
| SCHEMBL11451911 | 0.82 | MAP3K14 (0.41) | MAP3K14GCGRCYP26A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4207325-A | DIURETIC, SALURETIC, ANTIHYPERTENSIVE AND ANTITHROMBOTIC PROPERTIES | BAYER AKTIENGESELLSCHAFT (DE) | 1980-06-10 | — | — | US | disclosed |
| US-4113872-A | DIURETICS, SALURETICS, ANTIHYPERTENSIVE, ANTITHROMBOTIC AGENTS | BAKER AKTIENGESELLSHAFT (DE) | 1978-09-12 | — | — | US | disclosed |
| US-4112109-A | DIURETIC, SALURETIC, ANTIHYPERTENSIVE, ANTITHROMBOTIC | BAYER AKTIENGESELLSCHAFT (DE) | 1978-09-05 | — | — | US | disclosed |
| US-4099011-A | DIURETIC, SALURETIC, HYPOTENSIVE, ANTITHROMBOTIC | BAYER AKTIENGESELLSCHAFT (DE) | 1978-07-04 | — | — | US | disclosed |