Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 19/20 | 0.79 |
| ▸ | MAPK9 | P45984 | 17/20 | 0.79 |
| ▸ | MAPK10 | P53779 | 12/20 | 0.79 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.79 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.79 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.79 |
| ▸ | CDK2 | P24941 | 1/20 | 0.79 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.79 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.71 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.71 |
| ▸ | KIT | P10721 | 1/20 | 0.69 |
| ▸ | AKT1 | P31749 | 1/20 | 0.69 |
| ▸ | GSK3B | P49841 | 1/20 | 0.69 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.69 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL157014 | 0.88 | MAPK8 (1.00) | MAPK8MAPK9MAPK10MAPK1PRKD2 | |
| SCHEMBL29405886 | 0.88 | MAPK8 (1.00) | MAPK8MAPK9MAPK10MAPK1PRKD2 | |
| SCHEMBL1145432 | 0.86 | MAPK8 (1.00) | MAPK8MAPK9MAPK10MAPK1PRKD2 | |
| SCHEMBL1144546 | 0.86 | MAPK8 (1.00) | MAPK8MAPK9MAPK10MAPK1PRKD2 | |
| SCHEMBL5803514 | 0.85 | MAPK8 (0.69) | MAPK8MAPK9MAPK10MAPK1PRKD2 | |
| SCHEMBL1145036 | 0.83 | MAPK8 (0.76) | MAPK8MAPK9MAPK10MAPK1PRKD2 | |
| SCHEMBL1145467 | 0.83 | MAPK8 (1.00) | MAPK8MAPK9MAPK10MAPK1PRKD2 | |
| SCHEMBL1145118 | 0.82 | RPS6KB1 (1.00) | MAPK8MAPK9MAPK10MAPK1PRKD2 | |
| SCHEMBL1145361 | 0.82 | MAPK8 (0.74) | MAPK8MAPK9MAPK10MAPK1PRKD2 | |
| SCHEMBL1145327 | 0.81 | MAPK8 (0.86) | MAPK8MAPK9MAPK10MAPK1PRKD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7888374-B2 | Inhibitors of c-jun N-terminal kinases | ABBOTT LABORATORIES (US) | 2011-02-15 | — | — | US | claimed |
| US-20060173050-A1 | Inhibitors of c-Jun N-terminal kinases | ABBVIE INC. | 2006-08-03 | — | — | US | claimed |
| US-7888374-B2 | Inhibitors of c-jun N-terminal kinases | ABBOTT LABORATORIES (US) | 2011-02-15 | — | — | US | disclosed |
| WO-2006083673-A2 | PYRIDINE DERIVATIVES USEFUL AS INHIBITORS OF C-JUN N-TERMINAL KINASES | ABBOTT LABORATORIES (US) | 2006-08-10 | — | — | WO | disclosed |
| US-20060173050-A1 | Inhibitors of c-Jun N-terminal kinases | ABBVIE INC. | 2006-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060173050-A1 | Inhibitors of c-Jun N-terminal kinases | MAPKAPK3, MAP3K3, MAPK3 | MAPK8 30/4885MAPK9 49/4885MAPK10 47/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.