Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 19/20 | 0.54 |
| ▸ | MAPK9 | P45984 | 15/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 8/20 | 0.54 |
| ▸ | RPS27 | P42677 | 2/20 | 0.54 |
| ▸ | CSF1R | P07333 | 5/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.54 |
| ▸ | PRKD2 | Q9BZL6 | 5/20 | 0.54 |
| ▸ | AKT1 | P31749 | 3/20 | 0.54 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.54 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.54 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.51 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.51 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.51 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.51 |
| ▸ | JUN | P05412 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | KIT | P10721 | 1/20 | 0.49 |
| ▸ | BLK | P51451 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12113069 | 0.95 | MAPK8 (0.56) | MAPK8MAPK9MAPK10RPS27CSF1R | |
| SCHEMBL12113177 | 0.90 | MAPK8 (0.52) | MAPK8MAPK9MAPK10RPS27CSF1R | |
| SCHEMBL1145423 | 0.86 | MAPK8 (0.59) | MAPK8MAPK9MAPK10RPS27CSF1R | |
| SCHEMBL1314174 | 0.85 | MAPK8 (0.60) | MAPK8MAPK9MAPK10RPS27CSF1R | |
| SCHEMBL1145397 | 0.85 | MAPK8 (0.59) | MAPK8MAPK9MAPK10RPS27CSF1R | |
| SCHEMBL13514301 | 0.83 | MAPK8 (0.70) | MAPK8MAPK9MAPK10RPS27CSF1R | |
| SCHEMBL1145420 | 0.83 | MAPK8 (0.55) | MAPK8MAPK9MAPK10RPS27CSF1R | |
| SCHEMBL1145271 | 0.82 | MAPK8 (0.59) | MAPK8MAPK9MAPK10RPS27CSF1R | |
| SCHEMBL1145233 | 0.82 | MAPK8 (0.56) | MAPK8MAPK9MAPK10RPS27CSF1R | |
| SCHEMBL1145231 | 0.82 | MAPK8 (0.56) | MAPK8MAPK9MAPK10RPS27CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7888374-B2 | Inhibitors of c-jun N-terminal kinases | ABBOTT LABORATORIES (US) | 2011-02-15 | — | — | US | disclosed |
| US-20060173050-A1 | Inhibitors of c-Jun N-terminal kinases | ABBVIE INC. | 2006-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060173050-A1 | Inhibitors of c-Jun N-terminal kinases | MAPKAPK3, MAP3K3, MAPK3 | MAPK8 30/4885MAPK9 49/4885MAPK10 47/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.