SCHEMBL11458482

SCHEMBL11458482

Cc1ccc(CCC(C)I)o1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.46
KDM4E B2RXH2 1/20 0.46
ESR2 Q92731 1/20 0.46
CHRM2 P08172 2/20 0.44
MEN1 O00255 1/20 0.44
CHRM4 P08173 1/20 0.44
CHRM5 P08912 1/20 0.44
CHRM1 P11229 1/20 0.44
CYP2C9 P11712 1/20 0.44
CHRM3 P20309 1/20 0.44
KMT2A Q03164 1/20 0.44
POLB P06746 2/20 0.39
TDP1 Q9NUW8 2/20 0.39
ALOX5 P09917 1/20 0.36
PKM P14618 1/20 0.36
CYP2D6 P10635 1/20 0.35
CYP2C19 P33261 1/20 0.35
ALDH1A1 P00352 2/20 0.34
NPC1 O15118 2/20 0.34
THRB P10828 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12462041 0.83 MAPT (0.49) MAPTKDM4EESR2CHRM2MEN1
SCHEMBL11457824 0.80 MAPT (0.46) MAPTKDM4EESR2CHRM2MEN1
SCHEMBL11100365 0.80 MAPT (0.46) MAPTKDM4EESR2CHRM2MEN1
SCHEMBL6475097 0.78 CHRM2 (0.58) MAPTKDM4EESR2CHRM2MEN1
SCHEMBL11095606 0.76 MAPT (0.43) MAPTKDM4EESR2CHRM2MEN1
SCHEMBL11096214 0.76 MAPT (0.43) MAPTKDM4EESR2CHRM2MEN1
SCHEMBL10999034 0.76 MAPT (0.43) MAPTKDM4EESR2CHRM2MEN1
SCHEMBL8748295 0.74 MAPT (0.53) MAPTKDM4EESR2CHRM2MEN1
SCHEMBL17221875 0.73 MAPT (0.48) MAPTKDM4EESR2CHRM2MEN1
SCHEMBL24199861 0.73 MAPT (0.41) MAPTKDM4EESR2CHRM2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4221713-A Cyclization substrates and related 11α-equatorially-substituted steroids AKZONA INCORPORATED (US) 1980-09-09 US disclosed