Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11463581 | 1.00 | POLB (0.44) | POLBMAPTKDM4EAPEX1RECQL | |
| SCHEMBL11463806 | 1.00 | POLB (0.44) | POLBMAPTKDM4EAPEX1RECQL | |
| SCHEMBL11471408 | 0.85 | KDM4E (0.48) | POLBMAPTKDM4EAPEX1RECQL | |
| SCHEMBL11471661 | 0.85 | KDM4E (0.48) | POLBMAPTKDM4EAPEX1RECQL | |
| SCHEMBL28738521 | 0.82 | POLB (0.44) | POLBMAPTKDM4EAPEX1RECQL | |
| SCHEMBL31059223 | 0.82 | POLB (0.44) | POLBMAPTKDM4EAPEX1RECQL | |
| SCHEMBL1714077 | 0.74 | KMT2A (0.54) | POLBMAPTKDM4EAPEX1RECQL | |
| SCHEMBL1714080 | 0.74 | KMT2A (0.54) | POLBMAPTKDM4EAPEX1RECQL | |
| SCHEMBL1428573 | 0.74 | MAOB (0.50) | RECQLTDP1KMT2APIK3CAMTOR | |
| SCHEMBL4332856 | 0.74 | MAOB (0.50) | RECQLTDP1KMT2APIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4198501-A | CATALYTIC REDUCTION | HOFFMANN-LA ROCHE INC. (US) | 1980-04-15 | — | — | US | disclosed |
| US-4137404-A | Synthesis of tryptophans | HOFFMANN-LA ROCHE INC. (US) | 1979-01-30 | — | — | US | disclosed |