8-Hydroxyguanosine

8-Hydroxyguanosine

SCHEMBL114651

Nc1nc2c([nH]c(=O)n2[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)[nH]1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PNP P00491 3/20 0.68
MEN1 O00255 1/20 0.60
KMT2A Q03164 1/20 0.60
TLR7 Q9NYK1 2/20 0.57
CYP3A4 P08684 1/20 0.54
MAPT P10636 1/20 0.54
HSPA5 P11021 1/20 0.44
HSPA8 P11142 1/20 0.44
LMNA P02545 3/20 0.44
MTOR P42345 2/20 0.44
SMN1; SMN2 Q16637 2/20 0.44
ALDH1A1 P00352 2/20 0.44
THRB P10828 1/20 0.44
MDM2 Q00987 1/20 0.44
NCOA1 Q15788 1/20 0.44
NCOA3 Q9Y6Q9 1/20 0.44
POLB P06746 1/20 0.44
GMNN O75496 1/20 0.44
TP53 P04637 1/20 0.44
NFKB1 P19838 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
8-Hydroxyguanosine SCHEMBL20419141 1.00 PNP (0.68) PNPMEN1KMT2ATLR7CYP3A4
8-Hydroxyguanosine SCHEMBL23982342 1.00 PNP (0.68) PNPMEN1KMT2ATLR7CYP3A4
8-Hydroxyguanosine SCHEMBL29374403 1.00 PNP (0.68) PNPMEN1KMT2ATLR7CYP3A4
8-Hydroxyguanosine SCHEMBL23633218 1.00 PNP (0.68) PNPMEN1KMT2ATLR7CYP3A4
SCHEMBL9343760 0.88 PNP (0.65) PNPMEN1KMT2ATLR7CYP3A4
SCHEMBL23982330 0.88 PNP (0.65) PNPMEN1KMT2ATLR7CYP3A4
SCHEMBL20418973 0.88 PNP (0.65) PNPMEN1KMT2ATLR7CYP3A4
SCHEMBL1229065 0.88 PNP (0.65) PNPMEN1KMT2ATLR7CYP3A4
SCHEMBL3381134 0.87 PNP (0.53) PNPMEN1KMT2ATLR7CYP3A4
SCHEMBL24052883 0.86 PNP (0.52) PNPMEN1KMT2ATLR7CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 11090 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122070938-A Method for improving anti-tumor response by enhancing cellular immune response 四川大学 2026-05-22 CN claimed
US-20260139030-A1 CHIMERIC PROTEINS FOR TREATING CUTANEOUS INFLAMMATION SHATTUCK LABS INC (US) 2026-05-21 US claimed
CN-122055140-A Pharmaceutical composition containing nucleic acid construct and medical application thereof 上海瑞宏迪医药有限公司 2026-05-15 CN claimed
US-12577554-B2 Methods for purification of messenger RNA TRANSLATE BIO, INC. (US) 2026-03-17 US claimed
US-20260069717-A1 MODIFIED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, AND USES THEREOF MODERNATX INC (US) 2026-03-12 US claimed
EP-4705481-A2 CIRCULAR RNA COMPOSITIONS AND METHODS Orna Therapeutics, Inc. (US) 2026-03-11 EP claimed
EP-4705468-A1 MAMMALIAN POLYCISTRONIC EXPRESSION SYSTEM FOR DIRECT TRANSLATION FROM RNA AND SECRETION OF CARGO California Institute of Technology (US) 2026-03-11 EP claimed
US-12569572-B2 Messenger RNA therapy for the treatment of Friedreich's ataxia TRANSLATE BIO, INC. (US) 2026-03-10 US claimed
EP-4696703-A2 NUCLEIC ACID MOLECULES AND USES THEREOF CureVac SE (DE) 2026-02-18 EP claimed
US-20260028616-A1 METHODS AND APPARATUS FOR DUPLEX NUCLEOTIDE PURIFICATION AGILENT TECHNOLOGIES, INC. (US) 2026-01-29 US claimed
WO-2001030989-A2 METHOD FOR CREATING DIVERGENT POPULATIONS OF NUCLEIC ACID MOLECULES AND PROTEINS CYTOS BIOTECHNOLOGY AG (US) 2001-05-03 WO claimed
WO-2000078941-A2 METHODS AND PRODUCTS FOR MANIPULATING UNCOUPLING PROTEIN EXPRESSION UNIVERSITY OF VERMONT AND STATE AGRICULTURAL COLLEGE (US) 2000-12-28 WO claimed
US-6063628-A Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA UNIVERSITY OF WASHINGTON (US) 2000-05-16 US claimed
EP-0948256-A1 INDUCTION OF VIRAL MUTATION BY INCORPORATION OF MISCODING RIBONUCLEOSIDE ANALOGS INTO VIRAL RNA THE UNIVERSITY OF WASHINGTON (US) 1999-10-13 EP claimed
WO-1998018324-A1 INDUCTION OF VIRAL MUTATION BY INCORPORATION OF MISCODING RIBONUCLEOSIDE ANALOGS INTO VIRAL RNA THE UNIVERSITY OF WASHINGTON (US) 1998-05-07 WO claimed
US-5317013-A Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives SCRIPPS CLINIC AND RESEARCH FOUNDATION (US) 1994-05-31 US claimed
US-4948730-A INDUCING INTERFERON PRODUCTION SCRIPPS CLINIC AND RESEARCH FOUNDATION (US) 1990-08-14 US claimed
US-4643992-A Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives SCRIPPS CLINIC AND RESEARCH FOUNDATION (US) 1987-02-17 US claimed
EP-0112632-A2 Use of 8-substituted guanine derivatives in the manufacture of a medicament. SCRIPPS CLINIC AND RESEARCH FOUNDATION (US) 1984-07-04 EP claimed
WO-1984001898-A1 MODULATION OF ANIMAL CELLULAR RESPONSES WITH COMPOSITIONS CONTAINNG 8-SUBSTITUTED GUANINE DERIVATIVES SCRIPPS CLINIC RES (US) 1984-05-24 WO claimed