Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 5/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 9/20 | 0.43 |
| ▸ | CYP3A5 | P20815 | 2/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11450225 | 0.87 | KCNA5 (0.48) | KCNA5CYP3A4CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL11459952 | 0.83 | KCNA5 (0.44) | KCNA5CYP3A4CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL11450927 | 0.79 | KCNA5 (0.47) | KCNA5CYP3A4CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL11469797 | 0.78 | KCNA5 (0.46) | KCNA5CYP3A4CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL10726693 | 0.78 | KCNA5 (0.46) | KCNA5CYP3A4CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL10729127 | 0.76 | KCNA5 (0.50) | KCNA5CYP3A4CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL11451096 | 0.75 | CYP11B1 (0.43) | KCNA5CYP3A4CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL10724785 | 0.74 | KCNA5 (0.51) | KCNA5CYP3A4CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL11293244 | 0.74 | CYP19A1 (0.44) | KCNA5CYP3A4CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL1380025 | 0.74 | KCNA5 (0.57) | KCNA5CYP3A4CYP2C9CYP2C19CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4186202-A | ANTIDEPRESSANTS | ASTRA LAKEMEDEL AKTIEBOLAG (SE) | 1980-01-29 | — | — | US | disclosed |
| US-4102887-A | ANTIDEPRESSANTS, ANXIETY RELIEVING | AKTIEBOLAGET ASTRA (SE) | 1978-07-25 | — | — | US | disclosed |