Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 13/20 | 0.53 |
| ▸ | SRC | P12931 | 7/20 | 0.53 |
| ▸ | PKMYT1 | Q99640 | 3/20 | 0.53 |
| ▸ | BCR | P11274 | 3/20 | 0.53 |
| ▸ | EPHB6 | O15197 | 2/20 | 0.53 |
| ▸ | EGFR | P00533 | 2/20 | 0.53 |
| ▸ | LCK | P06239 | 2/20 | 0.53 |
| ▸ | FYN | P06241 | 2/20 | 0.53 |
| ▸ | CSF1R | P07333 | 2/20 | 0.53 |
| ▸ | YES1 | P07947 | 2/20 | 0.53 |
| ▸ | LYN | P07948 | 2/20 | 0.53 |
| ▸ | RET | P07949 | 2/20 | 0.53 |
| ▸ | HCK | P08631 | 2/20 | 0.53 |
| ▸ | KIT | P10721 | 2/20 | 0.53 |
| ▸ | BRAF | P15056 | 2/20 | 0.53 |
| ▸ | EPHA1 | P21709 | 2/20 | 0.53 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.53 |
| ▸ | EPHA3 | P29320 | 2/20 | 0.53 |
| ▸ | EPHA8 | P29322 | 2/20 | 0.53 |
| ▸ | EPHB2 | P29323 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1147168 | 0.88 | HDAC1 (0.57) | ABL1SRCPKMYT1BCREPHB6 | |
| SCHEMBL1147178 | 0.87 | HDAC1 (0.57) | ABL1SRCPKMYT1BCREPHB6 | |
| SCHEMBL1147078 | 0.86 | HDAC1 (0.58) | ABL1SRCPKMYT1BCREPHB6 | |
| SCHEMBL1147002 | 0.86 | HDAC1 (0.58) | ABL1SRCPKMYT1BCREPHB6 | |
| SCHEMBL1147167 | 0.85 | ABL1 (0.55) | ABL1SRCPKMYT1BCREPHB6 | |
| SCHEMBL15969973 | 0.84 | ABL1 (0.64) | ABL1SRCPKMYT1BCREPHB6 | |
| SCHEMBL1146862 | 0.83 | ABL1 (0.77) | ABL1SRCPKMYT1BCREPHB6 | |
| SCHEMBL19436382 | 0.80 | ABL1 (0.48) | ABL1SRCPKMYT1BCREPHB6 | |
| SCHEMBL22092305 | 0.78 | LCK (0.50) | ABL1SRCPKMYT1BCREPHB6 | |
| SCHEMBL17471511 | 0.76 | ABL1 (0.75) | ABL1SRCPKMYT1BCREPHB6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9169244-B2 | Tyrosine kinase inhibitors containing a zinc binding moiety | CURIS, INC. (US) | 2015-10-27 | — | — | US | disclosed |
| US-20140128410-A1 | TYROSINE KINASE INHIBITORS CONTAINING A ZINC BINDING MOIETY | CURIS, INC. (US) | 2014-05-08 | — | — | US | disclosed |
| US-8426419-B2 | Tyrosine kinase inhibitors containing a zinc binding moiety | CURIS, INC. (US) | 2013-04-23 | — | — | US | disclosed |
| US-20110178095-A1 | TYROSINE KINASE INHIBITORS CONTAINING A ZINC BINDING MOIETY | CURIS, INC. | 2011-07-21 | — | — | US | disclosed |
| US-7888361-B2 | anticancer; inhibits both BCR-ABL and histone deacetylase activity; N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-(hydroxyamino)-2-oxoethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide | CURIS, INC. (US) | 2011-02-15 | — | — | US | disclosed |
| US-20080221132-A1 | Multi-Functional Small Molecules as Anti-Proliferative Agents | CURIS, INC. | 2008-09-11 | — | — | US | disclosed |
| US-20080125440-A1 | TYROSINE KINASE INHIBITORS CONTAINING A ZINC BINDING MOIETY | CURIS, INC. | 2008-05-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221132-A1 | Multi-Functional Small Molecules as Anti-Proliferative Agents | HDAC1, HDAC6, HDAC5 | ABL1 1691/4885SRC 901/4885PKMYT1 3615/4885 |
| US-20110178095-A1 | TYROSINE KINASE INHIBITORS CONTAINING A ZINC BINDING MOIETY | LCK, ABL1, SRC | ABL1 2/4885SRC 3/4885PKMYT1 433/4885 |
| US-20140128410-A1 | TYROSINE KINASE INHIBITORS CONTAINING A ZINC BINDING MOIETY | LCK, ABL1, SRC | ABL1 2/4885SRC 3/4885PKMYT1 433/4885 |
| US-20080125440-A1 | TYROSINE KINASE INHIBITORS CONTAINING A ZINC BINDING MOIETY | LCK, ABL1, SRC | ABL1 2/4885SRC 3/4885PKMYT1 433/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.