Tracazolate

Tracazolate

SCHEMBL114769

CCCCNc1c(C(=O)OCC)c(C)nc2c1cnn2CC

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 1.00
GMNN O75496 1/20 1.00
USP2 O75604 1/20 1.00
ALDH1A1 P00352 1/20 1.00
LMNA P02545 1/20 1.00
TP53 P04637 1/20 1.00
CYP1A2 P05177 1/20 1.00
CYP3A4 P08684 1/20 1.00
CYP2D6 P10635 1/20 1.00
MAPT P10636 1/20 1.00
CYP2C9 P11712 1/20 1.00
TSHR P16473 1/20 1.00
MAPK1 P28482 1/20 1.00
CYP2C19 P33261 1/20 1.00
THPO P40225 1/20 1.00
BLM P54132 1/20 1.00
PMP22 Q01453 1/20 1.00
KMT2A Q03164 1/20 1.00
SMN1; SMN2 Q16637 1/20 1.00
NPSR1 Q6W5P4 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tracazolate SCHEMBL1061780 0.99 MEN1 (0.98) MEN1GMNNUSP2ALDH1A1LMNA
SCHEMBL1052855 0.93 MEN1 (0.87) MEN1GMNNUSP2ALDH1A1LMNA
SCHEMBL5928052 0.89 MEN1 (0.80) MEN1GMNNUSP2ALDH1A1LMNA
SCHEMBL1058802 0.89 MEN1 (0.79) MEN1GMNNUSP2ALDH1A1LMNA
SCHEMBL10977215 0.88 MEN1 (0.78) MEN1GMNNUSP2ALDH1A1LMNA
SCHEMBL10974754 0.86 MEN1 (0.76) MEN1GMNNUSP2ALDH1A1LMNA
SCHEMBL1059216 0.85 MEN1 (0.73) MEN1GMNNUSP2ALDH1A1LMNA
SCHEMBL2897824 0.84 MEN1 (0.72) MEN1GMNNUSP2ALDH1A1LMNA
Cartazolate SCHEMBL123839 0.82 PDE4B (1.00) MEN1GMNNUSP2ALDH1A1LMNA
SCHEMBL5927862 0.81 MEN1 (0.69) MEN1GMNNUSP2ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2748 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4622640-A1 COMPOSITIONS AND METHODS FOR MODULATING SLEEP AND USES THEREOF Brightseed, Inc. (US) 2025-10-01 EP claimed
US-20250281451-A1 COMPOSITIONS AND METHODS FOR MODULATING SLEEP AND USES THEREOF BRIGHTSEED, INC. 2025-09-11 US claimed
US-20240238250-A1 METHOD OF USING PIROMELATINE FOR TREATING PARASOMNIAS ASSOCIATED WITH LOSS OF REM SLEEP ATONIA NEURIM PHARMACEUTICALS (1991) LTD. (IL) 2024-07-18 US claimed
WO-2024150170-A1 PIROMELATINE FOR TREATING PARASOMNIAS ASSOCIATED WITH LOSS OF REM SLEEP ATONIA NEURIM PHARMACEUTICALS (1991) LTD. (IL) 2024-07-18 WO claimed
WO-2024112947-A1 COMPOSITIONS AND METHODS FOR MODULATING SLEEP AND USES THEREOF BRIGHTSEED, INC. (US) 2024-05-30 WO claimed
EP-4178948-A2 FUNCTIONALIZED ISONITRILES AND PRODUCTS, PREPARATION AND USES THEREOF Universidade de Santiago de Compostela (ES) 2023-05-17 EP claimed
WO-2022023496-A2 FUNCTIONALIZED ISONITRILES AND PRODUCTS, PREPARATION AND USES THEREOF UNIVERSIDADE DE SANTIAGO DE COMPOSTELA (ES) 2022-02-03 WO claimed
US-10689373-B2 1,2-substituted cyclopentanes as orexin receptor antagonists TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2020-06-23 US claimed
US-20190282580-A1 PRO-INFLAMMATORY ROLE FOR ADENOSINE UPTAKE AND METABOLISM LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY 2019-09-19 US claimed
US-20190275048-A1 METHOD OF TREATING INSOMNIA ROSENBERG LEON I (US) 2019-09-12 US claimed
US-20040152713-A1 Methods for treating joint pain or improving sleep using an estrogen agonist/antagonist PFIZER INC. 2004-08-05 US claimed
WO-2004064832-A2 METHODS FOR TREATING JOINT PAIN OR IMPROVING SLEEP USING AN ESTROGEN AGONIST/ANTAGONIST PFIZER PRODUCTS INC. (US) 2004-08-05 WO claimed
EP-1328261-A2 TREATMENT OF NEURODEGENERATIVE DISEASE Minerva Biotechnologies Corporation (US) 2003-07-23 EP claimed
US-20030060487-A1 Treatment of neurodegenerative disease MINERVA BIOTECHNOLOGIES CORPORATION 2003-03-27 US claimed
WO-2001078709-A2 TREATMENT OF NEURODEGENERATIVE DISEASE MINERVA BIOTECHNOLOGIES CORPORATION (US) 2001-10-25 WO claimed
JP-2000511885-A 2000-09-12 JP claimed
EP-0900086-A4 ENHANCEMENT OF SLEEP WITH A GROWTH HORMONE SECRETAGOGUE MERCK & CO INC (US) 2000-01-12 EP claimed
EP-0900086-A1 ENHANCEMENT OF SLEEP WITH A GROWTH HORMONE SECRETAGOGUE Merck & Co., Inc. (US) 1999-03-10 EP claimed
WO-1997041879-A1 ENHANCEMENT OF SLEEP WITH A GROWTH HORMONE SECRETAGOGUE MERCK & CO., INC. (US) 1997-11-13 WO claimed
EP-0174342-B1 BRAIN-SPECIFIC ANALOGUES OF CENTRALLY ACTING AMINES UNIVERSITY OF FLORIDA (US) 1989-12-20 EP claimed