Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 2/20 | 0.42 |
| ▸ | MDM4 | O15151 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | FABP5 | Q01469 | 3/20 | 0.39 |
| ▸ | FABP7 | O15540 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1147880 | 1.00 | KMT2A (0.48) | KMT2AEPHX2CASP3MDM4TP53 | |
| SCHEMBL1147745 | 0.94 | KMT2A (0.47) | KMT2AEPHX2CASP3MDM4TP53 | |
| SCHEMBL1148069 | 0.94 | KMT2A (0.47) | KMT2AEPHX2CASP3MDM4TP53 | |
| SCHEMBL1147542 | 0.92 | KMT2A (0.45) | KMT2AEPHX2CASP3MDM4TP53 | |
| SCHEMBL22558273 | 0.89 | KMT2A (0.45) | KMT2AEPHX2CASP3MDM4TP53 | |
| SCHEMBL22558284 | 0.89 | KMT2A (0.45) | KMT2AEPHX2CASP3MDM4TP53 | |
| SCHEMBL1148000 | 0.87 | KMT2A (0.52) | KMT2AEPHX2CASP3MDM4TP53 | |
| SCHEMBL1147971 | 0.87 | KMT2A (0.52) | KMT2AEPHX2CASP3MDM4TP53 | |
| SCHEMBL1147743 | 0.84 | KMT2A (0.47) | KMT2AEPHX2CASP3MDM4TP53 | |
| SCHEMBL1148068 | 0.84 | KMT2A (0.47) | KMT2AEPHX2CASP3MDM4TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180305400-A1 | STABILIZED COMPOUNDS HAVING SECONDARY STRUCTURE MOTIFS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2018-10-25 | — | — | US | disclosed |
| US-9951099-B2 | Stabilized compounds having secondary structure motifs | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2018-04-24 | — | — | US | disclosed |
| US-20170088581-A1 | STABILIZED COMPOUNDS HAVING SECONDARY STRUCTURE MOTIFS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-03-30 | — | — | US | disclosed |
| US-9505801-B2 | Stabilized compounds having secondary structure motifs | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-11-29 | — | — | US | disclosed |
| US-8895699-B2 | Stabilized compounds having secondary structure motifs | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2014-11-25 | — | — | US | disclosed |
| US-20140162339-A1 | Stabilized Compounds Having Secondary Structure Motifs | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2014-06-12 | — | — | US | disclosed |
| US-20130211046-A1 | Stabilized Compounds Having Secondary Structure Motifs | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2013-08-15 | — | — | US | disclosed |
| US-8324428-B2 | Stabilized compounds having secondary structure motifs | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-12-04 | — | — | US | disclosed |
| US-20110028753-A1 | Stabilized Compounds Having Secondary Structure Motifs | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-02-03 | — | — | US | disclosed |
| US-7786072-B2 | synthesizing a peptide from a selected number of natural or non-natural amino acids; stabilized p53 donor helical peptides | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-08-31 | — | — | US | disclosed |
| US-7192713-B1 | synthesizing a peptide from a selected number of natural or non-natural amino acids; stabilized p53 donor helical peptides | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2007-03-20 | — | — | US | disclosed |
| US-20060008848-A1 | synthesizing a peptide from a selected number of natural or non-natural amino acids; stabilized p53 donor helical peptides | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2006-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110028753-A1 | Stabilized Compounds Having Secondary Structure Motifs | TP53, MDM2, TP53BP1 | KMT2A 2534/4885EPHX2 3187/4885CASP3 1435/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.