Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | MCOLN2 | Q8IZK6 | 1/20 | 0.34 |
| ▸ | MCOLN1 | Q9GZU1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11482461 | 1.00 | CHRNA7 (0.38) | CHRNA7CHRNB4CHRNA3SIGMAR1TDP1 | |
| SCHEMBL5888768 | 0.98 | CHRNB4 (0.37) | CHRNA7CHRNB4CHRNA3SIGMAR1TDP1 | |
| SCHEMBL13463493 | 0.98 | CHRNB4 (0.37) | CHRNA7CHRNB4CHRNA3SIGMAR1TDP1 | |
| SCHEMBL10366438 | 0.96 | CHRNA7 (0.41) | CHRNA7CHRNB4CHRNA3SIGMAR1TDP1 | |
| SCHEMBL8761967 | 0.96 | CHRNA7 (0.41) | CHRNA7CHRNB4CHRNA3SIGMAR1TDP1 | |
| SCHEMBL8761961 | 0.96 | CHRNA7 (0.41) | CHRNA7CHRNB4CHRNA3SIGMAR1TDP1 | |
| SCHEMBL10366436 | 0.96 | CHRNA7 (0.41) | CHRNA7CHRNB4CHRNA3SIGMAR1TDP1 | |
| SCHEMBL11465447 | 0.96 | CHRNA7 (0.41) | CHRNA7CHRNB4CHRNA3SIGMAR1TDP1 | |
| SCHEMBL10366437 | 0.96 | CHRNA7 (0.41) | CHRNA7CHRNB4CHRNA3SIGMAR1TDP1 | |
| SCHEMBL8762939 | 0.93 | TDP1 (0.41) | CHRNA7CHRNB4CHRNA3SIGMAR1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4192885-A | Analgesic N-{2-[N'-(2-furylmethyl and 2-thienyl-methyl)-N'-alkylamino]cycloaliphatic}cyanobenzamides | THE UPJOHN COMPANY (US) | 1980-03-11 | — | — | US | disclosed |
| US-4153717-A | 260/332.2 R | THE UPJOHN COMPANY (US) | 1979-05-08 | — | — | US | disclosed |
| US-4148914-A | Analgesic N-(2-aminocyclo aliphatic)cyanobenzamides | THE UPJOHN COMPANY (US) | 1979-04-10 | — | — | US | disclosed |