Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.66 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL115032 | 0.88 | PIK3CA (0.51) | PIK3CAPIK3R1MTOR | |
| SCHEMBL113560 | 0.86 | PIK3CA (0.49) | PIK3CAPIK3R1MTOR | |
| SCHEMBL116104 | 0.84 | PIK3CA (0.67) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL114333 | 0.83 | PIK3CA (0.68) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL114876 | 0.81 | PIK3CA (0.71) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL112536 | 0.80 | PIK3CA (1.00) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL114471 | 0.79 | PIK3CA (0.70) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL116103 | 0.74 | PIK3CA (0.71) | PIK3CAPIK3R1MTOR | |
| SCHEMBL114428 | 0.73 | PIK3CA (1.00) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL114267 | 0.72 | PIK3CA (1.00) | PIK3CAPIK3R1MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424859-A1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | Amgen, Inc (US) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010126895-A1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | AMGEN INC. (US) | 2010-11-04 | — | — | WO | disclosed |