Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.45 |
| ▸ | MYC | P01106 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11489446 | 0.84 | TSHR (0.71) | TSHRPDE10AMYCKDM4E | |
| SCHEMBL11563775 | 0.83 | TSHR (0.54) | TSHRMYCKDM4ENR4A2 | |
| SCHEMBL734149 | 0.83 | PIK3CG (0.54) | PDE10APIK3CDPIK3CGPIK3CBKDM4E | |
| SCHEMBL734099 | 0.82 | PIK3CG (0.59) | PDE10APIK3CDPIK3CGPIK3CBKDM4E | |
| SCHEMBL733511 | 0.81 | PIK3CD (0.61) | PDE10APIK3CDPIK3CGPIK3CBKDM4E | |
| SCHEMBL11473835 | 0.80 | TSHR (0.55) | TSHRPDE10AMYCKDM4E | |
| SCHEMBL733278 | 0.79 | PIK3CG (0.56) | PDE10APIK3CDPIK3CGPIK3CBKDM4E | |
| SCHEMBL11486300 | 0.79 | TSHR (0.54) | TSHR | |
| SCHEMBL11478099 | 0.77 | TSHR (0.54) | TSHRMYCKDM4E | |
| SCHEMBL11482821 | 0.77 | TSHR (0.56) | TSHRPDE10AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4187306-A | Benzodiazepine-diones, a process for their production and their use as medicaments | BAYER AKTIENGESELLSCHAFT (DE) | 1980-02-05 | — | — | US | disclosed |
| EP-0000538-A1 | 6,7-Dihydro-5H,13H-quinazolino(3,2-a)(1,4)benzodiazepine-5,13-diones, process for their preparation and their use as medicaments. | BAYER AG (DE) | 1979-02-07 | — | — | EP | disclosed |