Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 13/20 | 0.62 |
| ▸ | KDR | P35968 | 10/20 | 0.62 |
| ▸ | TEK | Q02763 | 7/20 | 0.62 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.62 |
| ▸ | JAK3 | P52333 | 4/20 | 0.62 |
| ▸ | KIT | P10721 | 3/20 | 0.52 |
| ▸ | BRAF | P15056 | 1/20 | 0.52 |
| ▸ | DDR2 | Q16832 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.48 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | BCR | P11274 | 1/20 | 0.46 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1149284 | 0.94 | LCK (0.59) | LCKKDRTEKMAPK14JAK3 | |
| SCHEMBL1149446 | 0.92 | LCK (0.67) | LCKKDRTEKMAPK14JAK3 | |
| SCHEMBL1148998 | 0.92 | LCK (0.67) | LCKKDRTEKMAPK14JAK3 | |
| SCHEMBL1077026 | 0.91 | LCK (0.61) | LCKKDRTEKMAPK14JAK3 | |
| SCHEMBL1149349 | 0.91 | LCK (0.66) | LCKKDRTEKMAPK14JAK3 | |
| SCHEMBL1149181 | 0.90 | LCK (0.65) | LCKKDRTEKMAPK14JAK3 | |
| SCHEMBL1079570 | 0.90 | KDR (0.64) | LCKKDRTEKMAPK14JAK3 | |
| SCHEMBL1078782 | 0.89 | LCK (0.63) | LCKKDRTEKMAPK14JAK3 | |
| SCHEMBL1149143 | 0.89 | LCK (0.63) | LCKKDRTEKMAPK14JAK3 | |
| SCHEMBL1077229 | 0.89 | ABL1 (0.53) | LCKKDRTEKMAPK14JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110039845-A1 | 2-AMINOQUINAZOLINE DERIVATIVE | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2011-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110039845-A1 | 2-AMINOQUINAZOLINE DERIVATIVE | H1-2, H1-3, H1-0 | LCK 3187/4885KDR 896/4885TEK 2366/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.