Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 9/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.61 |
| ▸ | KDR | P35968 | 7/20 | 0.61 |
| ▸ | JAK3 | P52333 | 4/20 | 0.61 |
| ▸ | TEK | Q02763 | 4/20 | 0.61 |
| ▸ | KIT | P10721 | 4/20 | 0.53 |
| ▸ | CSF1R | P07333 | 1/20 | 0.53 |
| ▸ | BTK | Q06187 | 1/20 | 0.53 |
| ▸ | BRAF | P15056 | 6/20 | 0.52 |
| ▸ | ABL1 | P00519 | 3/20 | 0.52 |
| ▸ | SRC | P12931 | 2/20 | 0.52 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.51 |
| ▸ | RAF1 | P04049 | 5/20 | 0.49 |
| ▸ | SYK | P43405 | 1/20 | 0.49 |
| ▸ | FES | P07332 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1149752 | 0.95 | LCK (0.64) | LCKMAPK14KDRJAK3TEK | |
| SCHEMBL1149125 | 0.94 | LCK (0.61) | LCKMAPK14KDRJAK3TEK | |
| SCHEMBL1149463 | 0.93 | LCK (0.59) | LCKMAPK14KDRJAK3TEK | |
| SCHEMBL1078560 | 0.93 | LCK (0.61) | LCKMAPK14KDRJAK3TEK | |
| SCHEMBL1149100 | 0.93 | LCK (0.63) | LCKMAPK14KDRJAK3TEK | |
| SCHEMBL1079169 | 0.91 | LCK (0.63) | LCKMAPK14KDRJAK3TEK | |
| SCHEMBL1149113 | 0.91 | KDR (0.62) | LCKMAPK14KDRJAK3TEK | |
| SCHEMBL1149482 | 0.90 | LCK (0.61) | LCKMAPK14KDRJAK3TEK | |
| SCHEMBL1076598 | 0.89 | LCK (0.60) | LCKMAPK14KDRJAK3TEK | |
| SCHEMBL1080552 | 0.89 | LCK (0.64) | LCKMAPK14KDRJAK3TEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110039845-A1 | 2-AMINOQUINAZOLINE DERIVATIVE | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2011-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110039845-A1 | 2-AMINOQUINAZOLINE DERIVATIVE | H1-2, H1-3, H1-0 | LCK 3187/4885MAPK14 2338/4885KDR 896/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.