Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 3/20 | 0.49 |
| ▸ | FAP | Q12884 | 2/20 | 0.49 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.49 |
| ▸ | PREP | P48147 | 1/20 | 0.49 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.49 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.49 |
| ▸ | XIAP | P98170 | 1/20 | 0.47 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.47 |
| ▸ | ACE | P12821 | 6/20 | 0.46 |
| ▸ | REN | P00797 | 4/20 | 0.46 |
| ▸ | F2 | P00734 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PEPD | P12955 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10954689 | 0.85 | XIAP (0.46) | FAPPREPXIAPFKBP5ACE | |
| SCHEMBL6656423 | 0.84 | ACE (0.49) | DPP4FAPDPP7PREPDPP8 | |
| SCHEMBL16620343 | 0.84 | ACE (0.49) | DPP4FAPDPP7PREPDPP8 | |
| SCHEMBL5178008 | 0.84 | DPP4 (0.48) | DPP4FAPDPP7PREPDPP8 | |
| SCHEMBL11435886 | 0.84 | NPSR1 (0.56) | DPP4FAPDPP7PREPDPP8 | |
| SCHEMBL13379994 | 0.83 | XIAP (0.49) | DPP4DPP8DPP9XIAPFKBP5 | |
| SCHEMBL15723438 | 0.82 | DPP4 (0.54) | DPP4FAPDPP7PREPDPP8 | |
| SCHEMBL22811041 | 0.81 | DPP4 (0.45) | DPP4FAPDPP7PREPDPP8 | |
| Bromide SCHEMBL11427137 | 0.80 | KDM4E (0.58) | DPP4FAPDPP7PREPDPP8 | |
| SCHEMBL7994236 | 0.80 | DPP4 (0.58) | DPP4FAPDPP7PREPDPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4176116-A | ELASTASE ENZYME INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 1979-11-27 | — | — | US | disclosed |