Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 2/20 | 0.68 |
| ▸ | ELANE | P08246 | 1/20 | 0.54 |
| ▸ | REN | P00797 | 1/20 | 0.54 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.52 |
| ▸ | ACE | P12821 | 3/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CMA1 | P23946 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11517511 | 0.93 | PREP (0.70) | PREPELANERENCTRB1ACE | |
| SCHEMBL7871516 | 0.90 | PREP (0.72) | PREPELANEACECYP3A4TSHR | |
| SCHEMBL7334484 | 0.90 | PREP (0.72) | PREPELANEACECYP3A4TSHR | |
| SCHEMBL22209468 | 0.90 | PREP (0.72) | PREPELANEACECYP3A4TSHR | |
| SCHEMBL11515816 | 0.90 | PREP (0.66) | PREPELANERENCTRB1ACE | |
| SCHEMBL16000756 | 0.89 | PREP (0.71) | PREPELANERENCTRB1ACE | |
| SCHEMBL11428845 | 0.89 | PREP (0.65) | PREPELANERENCTRB1ACE | |
| SCHEMBL8198229 | 0.88 | PREP (0.70) | PREPELANERENCTRB1ACE | |
| SCHEMBL22209424 | 0.88 | PREP (0.70) | PREPELANERENCTRB1ACE | |
| SCHEMBL7305929 | 0.88 | PREP (0.70) | PREPELANERENCTRB1ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4176116-A | ELASTASE ENZYME INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 1979-11-27 | — | — | US | disclosed |