Histidine

Histidine

SCHEMBL11520178

Cn1cnc(CC(N)C(=O)O)c1.NC(Cc1c[nH]cn1)C(=O)O

nearest known ligand 0.39

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 1/20 0.39
TSHR P16473 1/20 0.39
CYP2C19 P33261 1/20 0.39
MTOR P42345 1/20 0.39
HRH4 Q9H3N8 1/20 0.39
HRH3 Q9Y5N1 1/20 0.39
GRIA1 P42261 5/20 0.38
GRIA2 P42262 5/20 0.38
GRIA3 P42263 5/20 0.38
GRIA4 P48058 5/20 0.38
TDP1 Q9NUW8 1/20 0.38
CYP3A4 P08684 1/20 0.38
SLC7A5 Q01650 1/20 0.38
CPB2 Q96IY4 8/20 0.37
CPB1 P15086 4/20 0.37
CYP1A2 P05177 1/20 0.37
GRIK1 P39086 2/20 0.35
GRIK2 Q13002 2/20 0.35
GRIK3 Q13003 2/20 0.35
GRIK4 Q16099 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL52216 0.89 CYP2C9 (0.47) CYP2C9TSHRCYP2C19MTORHRH4
SCHEMBL163222 0.89 CYP2C9 (0.47) CYP2C9TSHRCYP2C19MTORHRH4
SCHEMBL52215 0.89 CYP2C9 (0.47) CYP2C9TSHRCYP2C19MTORHRH4
Hydrochloric Acid SCHEMBL3843450 0.87 TDP1 (0.49) CYP2C9TSHRCYP2C19MTORHRH4
Histidine SCHEMBL30167269 0.87 SLC7A5 (0.46) CYP2C9TSHRGRIA1GRIA2GRIA3
Histidine SCHEMBL30038780 0.87 SLC7A5 (0.46) CYP2C9TSHRGRIA1GRIA2GRIA3
Histidine SCHEMBL123617 0.87 SLC7A5 (0.46) CYP2C9TSHRGRIA1GRIA2GRIA3
Histidine SCHEMBL28977984 0.87 SLC7A5 (0.46) CYP2C9TSHRGRIA1GRIA2GRIA3
Histidine SCHEMBL1032558 0.87 SLC7A5 (0.46) CYP2C9TSHRGRIA1GRIA2GRIA3
Histidine SCHEMBL30167258 0.87 SLC7A5 (0.46) CYP2C9TSHRGRIA1GRIA2GRIA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115379828-A Compositions and methods for treating and preventing pulmonary disorders 代表亚利桑那大学的亚利桑那校董会 2022-11-22 CN disclosed
US-4133753-A Method of ion exchange chromatography HITACHI, LTD. (JP) 1979-01-09 US disclosed