Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | CA1 | P00915 | 4/20 | 0.44 |
| ▸ | CA2 | P00918 | 4/20 | 0.44 |
| ▸ | CA9 | Q16790 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.40 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11520297 | 0.93 | NPC1 (0.55) | NPC1KMT2AMEN1CA1CA2 | |
| SCHEMBL11518189 | 0.86 | KMT2A (0.64) | NPC1KMT2AMEN1CA1CA2 | |
| SCHEMBL11524007 | 0.85 | NPC1 (0.52) | NPC1KMT2AMEN1CA1CA2 | |
| SCHEMBL11522923 | 0.84 | NPC1 (0.56) | NPC1KMT2AMEN1CA1CA2 | |
| SCHEMBL11518731 | 0.82 | NPC1 (0.51) | NPC1KMT2AMEN1CA1CA2 | |
| SCHEMBL11522463 | 0.82 | NPC1 (0.51) | NPC1KMT2AMEN1CA1CA2 | |
| SCHEMBL11521529 | 0.81 | NPC1 (0.53) | NPC1KMT2AMEN1CA1CA2 | |
| SCHEMBL11521258 | 0.81 | NPC1 (0.58) | NPC1KMT2AMEN1CA1CA2 | |
| SCHEMBL11519378 | 0.80 | NPC1 (0.56) | NPC1KMT2AMEN1CA1CA2 | |
| SCHEMBL11523185 | 0.80 | KMT2A (0.63) | NPC1KMT2AMEN1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4176192-A | ANTHELMINTICS | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-11-27 | — | — | US | disclosed |