Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 7/20 | 0.45 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.44 |
| ▸ | MIF | P14174 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KMO | O15229 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | MME | P08473 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Picotrin SCHEMBL2109455 | 0.93 | P4HTM (0.50) | P4HTMP4HA1MIFKDM4EALDH1A1 | |
| SCHEMBL11536458 | 0.86 | P4HTM (0.52) | P4HTMP4HA1MIFKDM4EALDH1A1 | |
| SCHEMBL11534152 | 0.86 | P4HTM (0.51) | P4HTMP4HA1MIFKDM4EALDH1A1 | |
| SCHEMBL11540602 | 0.86 | P4HTM (0.51) | P4HTMP4HA1MIFKDM4EALDH1A1 | |
| SCHEMBL11538266 | 0.82 | P4HTM (0.51) | P4HTMKDM4EALDH1A1L3MBTL1 | |
| Picotrin SCHEMBL635327 | 0.81 | KDM4E (0.44) | P4HTMP4HA1MIFKDM4EALDH1A1 | |
| SCHEMBL11535031 | 0.81 | KCNN4 (0.46) | P4HTMP4HA1MIFKDM4EALDH1A1 | |
| SCHEMBL11536461 | 0.81 | KDM4E (0.49) | P4HTMP4HA1MIFKDM4EALDH1A1 | |
| SCHEMBL71034 | 0.81 | HIF1A (0.55) | P4HTMP4HA1MIFKDM4EALDH1A1 | |
| SCHEMBL29929320 | 0.81 | HIF1A (0.55) | P4HTMP4HA1MIFKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4139625-A | 5-(Substituted triphenylmethyl)picolinamides and their use as anti-acne agents | SCHERING CORPORATION (US) | 1979-02-13 | — | — | US | disclosed |
| US-4133887-A | Trityl picolinic acid derivatives and their use as anti-acne agents | SCHERING CORPORATION (US) | 1979-01-09 | — | — | US | disclosed |
| US-4127662-A | ANTIACNE | SCHERING CORPORATION (US) | 1978-11-28 | — | — | US | disclosed |
| US-4123433-A | ANTIACNE AGENTS | SCHERING CORPORATION (US) | 1978-10-31 | — | — | US | disclosed |
| US-4044140-A | Trityl picolinic acid derivatives and their use as anti-acne agents | SCHERING CORPORATION (US) | 1977-08-23 | — | — | US | disclosed |