Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.56 |
| ▸ | MTOR | P42345 | 3/20 | 0.45 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL115504 | 0.86 | PIK3CA (0.70) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL114964 | 0.85 | AVPR1B (0.38) | PIK3CA | |
| SCHEMBL167612 | 0.81 | PIK3CA (0.72) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL114370 | 0.78 | PIK3CA (0.66) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL115993 | 0.77 | PIK3CA (0.71) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL3116321 | 0.74 | PIK3CA (0.73) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL166354 | 0.74 | PIK3CA (0.74) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL166355 | 0.74 | PIK3CA (0.74) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL165802 | 0.74 | PIK3CA (0.71) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL114164 | 0.73 | PIK3CA (0.60) | PIK3CAMTORPIK3R1PIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424859-A1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | Amgen, Inc (US) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010126895-A1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | AMGEN INC. (US) | 2010-11-04 | — | — | WO | disclosed |