Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 13/20 | 0.60 |
| ▸ | ACE2 | Q9BYF1 | 3/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7386490 | 0.85 | ACE (0.57) | ACEACE2 | |
| SCHEMBL11548225 | 0.84 | ACE (0.55) | ACEACE2 | |
| SCHEMBL3144462 | 0.82 | ACE (0.64) | ACEACE2NPC1SMN1; SMN2 | |
| SCHEMBL5742165 | 0.82 | ACE (0.64) | ACEACE2NPC1SMN1; SMN2 | |
| SCHEMBL11547640 | 0.82 | ACE (0.58) | ACEACE2 | |
| SCHEMBL474618 | 0.81 | ACE (0.60) | ACEACE2SMN1; SMN2ALDH1A1 | |
| SCHEMBL474742 | 0.81 | ACE (0.60) | ACEACE2SMN1; SMN2ALDH1A1 | |
| SCHEMBL5742191 | 0.81 | SMN1; SMN2 (0.52) | ACEACE2SMN1; SMN2ALDH1A1 | |
| SCHEMBL5742195 | 0.81 | SMN1; SMN2 (0.52) | ACEACE2SMN1; SMN2ALDH1A1 | |
| SCHEMBL28650436 | 0.80 | ACE (0.58) | ACEACE2SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4154840-A | Antihypertensive pipecolic acid derivatives | E. R. SQUIBB & SONS, INC. (US) | 1979-05-15 | — | — | US | disclosed |
| US-4105776-A | ANGIOTENSIN CONVERTING ENZYME INHIBITORS, HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1978-08-08 | — | — | US | disclosed |