Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.61 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.45 |
| ▸ | DPP4 | P27487 | 4/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.41 |
| ▸ | DPP9 | Q86TI2 | 4/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.40 |
| ▸ | TMPRSS15 | P98073 | 2/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.39 |
| ▸ | FAP | Q12884 | 1/20 | 0.39 |
| ▸ | ACE | P12821 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4254807 | 0.86 | ATM (0.65) | ATMPIK3CDDPP4DPP8DPP9 | |
| SCHEMBL4251347 | 0.86 | ATM (0.65) | ATMPIK3CDDPP4DPP8DPP9 | |
| SCHEMBL4255717 | 0.86 | ATM (0.65) | ATMPIK3CDDPP4DPP8DPP9 | |
| SCHEMBL12112073 | 0.86 | ATM (0.65) | ATMPIK3CDDPP4DPP8DPP9 | |
| SCHEMBL4254305 | 0.86 | ATM (0.65) | ATMPIK3CDDPP4DPP8DPP9 | |
| SCHEMBL4251344 | 0.86 | ATM (0.65) | ATMPIK3CDDPP4DPP8DPP9 | |
| SCHEMBL4254805 | 0.86 | ATM (0.65) | ATMPIK3CDDPP4DPP8DPP9 | |
| SCHEMBL4441243 | 0.83 | ATM (0.61) | ATMPIK3CDDPP4DPP8DPP9 | |
| SCHEMBL4441246 | 0.83 | ATM (0.61) | ATMPIK3CDDPP4DPP8DPP9 | |
| SCHEMBL15756825 | 0.83 | ATM (0.61) | ATMPIK3CDDPP4DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4154937-A | ANGIOTENSIN CONVERTING ENZYME INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1979-05-15 | — | — | US | disclosed |
| US-4128653-A | Reduction of blood pressure with carboxyalkylacyl-pipecolic acid derivatives | E. R. SQUIBB & SONS, INC. (US) | 1978-12-05 | — | — | US | disclosed |
| US-4086338-A | HYPOTENSIVE AGENTS, ANGIOTENSIN CONVERTING ENZYME INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1978-04-25 | — | — | US | disclosed |
| US-4052511-A | ANGIOTENSIN CONVERTING ENZYME INHIBITORS | E. R. SQUIBB & SONS, INC. (US) | 1977-10-04 | — | — | US | disclosed |