Erythromycin

SCHEMBL11567231

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nearest known ligand 0.75

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

rplA rplB rplC rplD rplE rplF rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmC rpmD rpmE rpmF rpmG rpmH rpmI rpmJ rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsS rpsT rpsU ykgM ykgO

The experimentally established mechanism targets of Erythromycin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	CYP3A4	P08684	10/20	0.75

▸	KCNH2	Q12809	6/20	0.75

▸	LMNA	P02545	3/20	0.75

▸	ABCB1	P08183	2/20	0.75

▸	TSHR	P16473	2/20	0.75

▸	MLNR	O43193	2/20	0.75

▸	TDP1	Q9NUW8	1/20	0.75

▸	ALB	P02768	1/20	0.75

▸	CNR1	P21554	1/20	0.75

▸	HTR2A	P28223	1/20	0.75

▸	AOX1	Q06278	1/20	0.75

▸	CYP1B1	Q16678	1/20	0.75

▸	SLCO1B3	Q9NPD5	2/20	0.70

▸	SLCO1B1	Q9Y6L6	2/20	0.70

▸	AR	P10275	1/20	0.70

▸	MAPK1	P28482	1/20	0.70

▸	ABCC4	O15439	1/20	0.65

▸	ABCB11	O95342	1/20	0.65

▸	PGR	P06401	1/20	0.65

▸	HTR1A	P08908	1/20	0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Roxithromycin SCHEMBL28086213	0.90	KCNH2 (0.79)	CYP3A4KCNH2LMNAABCB1TSHR
Troleandomycin SCHEMBL13724014	0.88	CYP3A4 (0.70)	CYP3A4KCNH2LMNAABCB1TSHR
Troleandomycin SCHEMBL28832632	0.88	CYP3A4 (0.70)	CYP3A4KCNH2LMNAABCB1TSHR
Erythromycin SCHEMBL2328474	0.87	CYP3A4 (1.00)	CYP3A4KCNH2LMNAABCB1TSHR
Erythromycin SCHEMBL13900514	0.87	CYP3A4 (1.00)	CYP3A4KCNH2LMNAABCB1TSHR
SCHEMBL23370295	0.87	CYP3A4 (0.81)	CYP3A4KCNH2LMNAABCB1TSHR
Erythromycin SCHEMBL15472911	0.87	CYP3A4 (1.00)	CYP3A4KCNH2LMNAABCB1TSHR
Erythromycin SCHEMBL14342511	0.87	CYP3A4 (1.00)	CYP3A4KCNH2LMNAABCB1TSHR
Erythromycin SCHEMBL20833993	0.87	CYP3A4 (1.00)	CYP3A4KCNH2LMNAABCB1TSHR
Erythromycin SCHEMBL24415240	0.87	CYP3A4 (1.00)	CYP3A4KCNH2LMNAABCB1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
JP-54095585-A	—	—	None	—	—	JP	disclosed
JP-S5495585-A	OLEANDOMYCINERYTHROMYCIN AND 4DEOXYY4* ALKYL AMIDE DERIVATIVE OF ERYTHROMYCIN CARBONATE	PFIZER	1979-07-28	—	—	JP	disclosed