Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 5/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | BMP1 | P13497 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL164880 | 0.93 | PIK3CA (0.49) | PIK3CAPIK3CDPIK3CBPIK3CGBMP1 | |
| SCHEMBL166143 | 0.86 | PIK3CA (0.48) | PIK3CAPIK3CDPIK3CBPIK3CGBMP1 | |
| SCHEMBL114991 | 0.84 | PIK3CA (0.68) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL114924 | 0.82 | PIK3CA (0.45) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL3108787 | 0.81 | PIK3CA (0.41) | PIK3CAMEN1KMT2APTGS1LMNA | |
| SCHEMBL167498 | 0.80 | PIK3CA (0.51) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL168049 | 0.80 | PIK3CA (0.43) | PIK3CAMEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL116627 | 0.80 | PIK3CA (0.49) | PIK3CAPIK3CDPIK3CBPIK3CGMEN1 | |
| SCHEMBL169240 | 0.80 | PIK3CA (0.44) | PIK3CAMEN1KMT2ALMNAAPLNR | |
| SCHEMBL166903 | 0.78 | PIK3CA (0.43) | PIK3CAMEN1KMT2ALMNAAPLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424859-A1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | Amgen, Inc (US) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010126895-A1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | AMGEN INC. (US) | 2010-11-04 | — | — | WO | disclosed |