Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 19/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 19/20 | 1.00 |
| ▸ | GAA | P10253 | 10/20 | 1.00 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.69 |
| ▸ | NPC1 | O15118 | 8/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.66 |
| ▸ | MAPT | P10636 | 3/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.66 |
| ▸ | RECQL | P46063 | 1/20 | 0.66 |
| ▸ | AR | P10275 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | HPN | P05981 | 1/20 | 0.59 |
| ▸ | IDE | P14735 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14709708 | 0.82 | MEN1 (0.69) | MEN1KMT2AGAAMCL1NPC1 | |
| SCHEMBL14709410 | 0.82 | MEN1 (0.69) | MEN1KMT2AGAAMCL1NPC1 | |
| SCHEMBL13035675 | 0.82 | MEN1 (0.84) | MEN1KMT2AGAAMCL1NPC1 | |
| SCHEMBL13035693 | 0.81 | MEN1 (1.00) | MEN1KMT2AGAAMCL1NPC1 | |
| SCHEMBL11568615 | 0.81 | MEN1 (1.00) | MEN1KMT2AGAAMCL1NPC1 | |
| SCHEMBL16229294 | 0.79 | MEN1 (0.68) | MEN1KMT2AGAAMCL1NPC1 | |
| SCHEMBL12858471 | 0.77 | AR (1.00) | MEN1KMT2AGAAMCL1NPC1 | |
| SCHEMBL11568648 | 0.76 | MEN1 (0.61) | MEN1KMT2AGAAMCL1NPC1 | |
| SCHEMBL14709352 | 0.75 | MEN1 (1.00) | MEN1KMT2AGAAMCL1NPC1 | |
| SCHEMBL14709209 | 0.75 | MEN1 (1.00) | MEN1KMT2AGAAMCL1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013023300-A1 | INHIBITORS OF ANDROGEN RECEPTOR ACTIVATION FUNCTION-2 (AF2) AS THERAPEUTICS AND METHODS FOR THEIR USE | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2013-02-21 | — | — | WO | disclosed |
| EP-0002906-A2 | Novel perimidines, their preparation, formulations and use as immunosuppressives | ELI LILLY AND COMPANY (US) | 1979-07-11 | — | — | EP | disclosed |