Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 2/20 | 0.51 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | F3 | P13726 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CCR6 | P51684 | 1/20 | 0.42 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SI | P14410 | 1/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8882866 | 1.00 | AKR1C3 (0.51) | AKR1C3AKR1C1MAPTHPGDSIRT1 | |
| SCHEMBL8882860 | 1.00 | AKR1C3 (0.51) | AKR1C3AKR1C1MAPTHPGDSIRT1 | |
| SCHEMBL11577013 | 0.90 | MAPT (0.56) | MAPTHPGDMAOBCYP1A2F3 | |
| SCHEMBL11577018 | 0.90 | MAPT (0.56) | MAPTHPGDMAOBCYP1A2F3 | |
| SCHEMBL9048079 | 0.80 | MAPT (0.47) | MAPTHPGDCYP1A2F3ALDH1A1 | |
| SCHEMBL8882040 | 0.77 | AKR1C3 (0.57) | AKR1C3AKR1C1MAPTHPGDMAOB | |
| SCHEMBL8145324 | 0.77 | AKR1C3 (0.57) | AKR1C3AKR1C1MAPTHPGDMAOB | |
| SCHEMBL8852927 | 0.77 | AKR1C3 (0.57) | AKR1C3AKR1C1MAPTHPGDMAOB | |
| SCHEMBL8884025 | 0.74 | NPC1 (0.61) | AKR1C3AKR1C1MAPTHPGDMAOB | |
| SCHEMBL8884023 | 0.74 | NPC1 (0.61) | AKR1C3AKR1C1MAPTHPGDMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4118558-A | ANTIINFLAMMATORY AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1978-10-03 | — | — | US | disclosed |
| US-4085142-A | ANTIINFLAMMATORY | E. R. SQUIBB & SONS, INC. (US) | 1978-04-18 | — | — | US | disclosed |