Sugi Predict

Sugi Predict / Compounds / SCHEMBL1158563

SCHEMBL1158563

SCHEMBL1158563

CC[C@@H](CO)Nc1nc(Nc2cc(C)ccn2)cc2ccn(CC)c(=O)c12

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SYK P43405 5/20 0.39
▸ CRHR1 P34998 4/20 0.36
▸ TYK2 P29597 3/20 0.35
▸ FDPS P14324 1/20 0.33
▸ CCNA2 P20248 3/20 0.33
▸ CDK2 P24941 3/20 0.33
▸ CDK5 Q00535 3/20 0.33
▸ CCNA1 P78396 2/20 0.33
▸ DYRK1A Q13627 2/20 0.33
▸ CDK5R1 Q15078 2/20 0.33
▸ KARS1 Q15046 1/20 0.33
▸ MAP4K4 O95819 1/20 0.33
▸ ABL1 P00519 1/20 0.33
▸ LCK P06239 1/20 0.33
▸ FYN P06241 1/20 0.33
▸ IGF1R P08069 1/20 0.33
▸ LTK P29376 1/20 0.33
▸ KDR P35968 1/20 0.33
▸ MAP2K2 P36507 1/20 0.33
▸ MAPK8 P45983 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1159979 1.00 SYK (0.39) SYKCRHR1TYK2FDPSCCNA2
SCHEMBL1159349 0.90 SYK (0.40) SYKTYK2FDPSCDK5KARS1
SCHEMBL1160129 0.90 SYK (0.40) SYKTYK2FDPSCDK5KARS1
SCHEMBL1158672 0.88 SYK (0.39) SYKTYK2FDPSCCNA2CDK2
SCHEMBL1159201 0.88 SYK (0.38) SYKTYK2FDPSCDK5KARS1
SCHEMBL1158436 0.88 SYK (0.44) SYKTYK2FDPSCDK5KARS1
SCHEMBL1158810 0.87 SYK (0.51) SYKCRHR1CCNA2CDK2CDK5
SCHEMBL6522605 0.87 SYK (0.51) SYKCRHR1CCNA2CDK2CDK5
SCHEMBL1159168 0.82 SYK (0.39) SYKTYK2CDK5KARS1MAP4K4
SCHEMBL1159066 0.82 SYK (0.39) SYKTYK2CDK5KARS1MAP4K4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2459556-A1 2, 7 -NAPHTHYRIDIN- 1 -ONE DERIVATIVES AS SYK KINASE INHIBITORS IRM LLC (BM) 2012-06-06 — — EP claimed
US-20110053897-A1 COMPOUNDS AND COMPOSITIONS AS SYK KINASE INHIBITORS IRM LLC (BM) 2011-03-03 — — US claimed
WO-2011014515-A1 2, 7 -NAPHTHYRIDIN- 1 -ONE DERIVATIVES AS SYK KINASE INHIBITORS IRM LLC (BM) 2011-02-03 — — WO claimed
EP-2459556-A1 2, 7 -NAPHTHYRIDIN- 1 -ONE DERIVATIVES AS SYK KINASE INHIBITORS IRM LLC (BM) 2012-06-06 — — EP disclosed
US-20110053897-A1 COMPOUNDS AND COMPOSITIONS AS SYK KINASE INHIBITORS IRM LLC (BM) 2011-03-03 — — US disclosed
US-20110053897-A1 COMPOUNDS AND COMPOSITIONS AS SYK KINASE INHIBITORS IRM LLC (BM) 2011-03-03 — — US disclosed
US-20110053897-A1 COMPOUNDS AND COMPOSITIONS AS SYK KINASE INHIBITORS IRM LLC (BM) 2011-03-03 — — US disclosed
WO-2011014515-A1 2, 7 -NAPHTHYRIDIN- 1 -ONE DERIVATIVES AS SYK KINASE INHIBITORS IRM LLC (BM) 2011-02-03 — — WO disclosed
WO-2011014515-A1 2, 7 -NAPHTHYRIDIN- 1 -ONE DERIVATIVES AS SYK KINASE INHIBITORS IRM LLC (BM) 2011-02-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110053897-A1 COMPOUNDS AND COMPOSITIONS AS SYK KINASE INHIBITORS SYK, BTK, LYN SYK 1/4885CRHR1 4853/4885TYK2 35/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.