Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 4/20 | 0.38 |
| ▸ | TYK2 | P29597 | 8/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 4/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1159514 | 0.92 | SYK (0.41) | SYKTYK2GRM2 | |
| SCHEMBL1159114 | 0.91 | TYK2 (0.43) | SYKTYK2GRM2 | |
| SCHEMBL1159214 | 0.90 | SYK (0.40) | SYKTYK2 | |
| SCHEMBL1159159 | 0.90 | SYK (0.41) | SYKTYK2GRM2 | |
| SCHEMBL1159578 | 0.89 | TYK2 (0.41) | SYKTYK2GRM2 | |
| SCHEMBL6523528 | 0.88 | SYK (0.42) | SYKTYK2GRM2 | |
| SCHEMBL12849048 | 0.88 | SYK (0.40) | SYKTYK2GRM2 | |
| SCHEMBL1159399 | 0.87 | SYK (0.40) | SYKTYK2GRM2 | |
| SCHEMBL6520478 | 0.85 | SYK (0.40) | SYKTYK2GRM2 | |
| SCHEMBL1158840 | 0.85 | SYK (0.38) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2459556-A1 | 2, 7 -NAPHTHYRIDIN- 1 -ONE DERIVATIVES AS SYK KINASE INHIBITORS | IRM LLC (BM) | 2012-06-06 | — | — | EP | claimed |
| WO-2011014515-A1 | 2, 7 -NAPHTHYRIDIN- 1 -ONE DERIVATIVES AS SYK KINASE INHIBITORS | IRM LLC (BM) | 2011-02-03 | — | — | WO | claimed |
| EP-2459556-A1 | 2, 7 -NAPHTHYRIDIN- 1 -ONE DERIVATIVES AS SYK KINASE INHIBITORS | IRM LLC (BM) | 2012-06-06 | — | — | EP | disclosed |
| WO-2011014515-A1 | 2, 7 -NAPHTHYRIDIN- 1 -ONE DERIVATIVES AS SYK KINASE INHIBITORS | IRM LLC (BM) | 2011-02-03 | — | — | WO | disclosed |