Sugi Predict

Sugi Predict / Compounds / SCHEMBL1159564

SCHEMBL1159564

SCHEMBL1159564

CC(C)Nc1nc(Nc2cc(-c3ccccc3)ccn2)cc2cc[nH]c(=O)c12

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ IDH2 P48735 1/20 0.40
▸ ZAP70 P43403 5/20 0.39
▸ FDPS P14324 1/20 0.39
▸ JAK2 O60674 4/20 0.39
▸ FER P16591 1/20 0.37
▸ SYK P43405 4/20 0.37
▸ BUB1 O43683 2/20 0.37
▸ CAMK2D Q13557 1/20 0.36
▸ MAP4K4 O95819 1/20 0.35
▸ ABL1 P00519 1/20 0.35
▸ LCK P06239 1/20 0.35
▸ FYN P06241 1/20 0.35
▸ IGF1R P08069 1/20 0.35
▸ LTK P29376 1/20 0.35
▸ KDR P35968 1/20 0.35
▸ MAP2K2 P36507 1/20 0.35
▸ MAPK8 P45983 1/20 0.35
▸ MAPK9 P45984 1/20 0.35
▸ CLK2 P49760 1/20 0.35
▸ GSK3A P49840 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1158920 0.90 FLT3 (0.45) IDH2ZAP70JAK2FERSYK
SCHEMBL1158174 0.85 JAK2 (0.41) ZAP70JAK2FERSYKLYN
SCHEMBL1158573 0.85 FER (0.43) ZAP70FDPSJAK2FERSYK
SCHEMBL6524344 0.85 CHEK1 (0.43) ZAP70JAK2SYKGSK3BACVR1
SCHEMBL1158371 0.84 TYK2 (0.43) ZAP70FDPSJAK2FERSYK
SCHEMBL1158649 0.82 ELANE (0.39) ZAP70JAK2FERSYKLYN
SCHEMBL1158912 0.82 SYK (0.40) ZAP70JAK2FERSYKABL1
SCHEMBL1158519 0.81 SYK (0.52) ZAP70JAK2FERSYKLYN
SCHEMBL1158369 0.81 PRKD1 (0.39) ZAP70FDPSJAK2FERSYK
SCHEMBL1158555 0.81 JAK2 (0.38) ZAP70JAK2FERSYKLYN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2459556-A1 2, 7 -NAPHTHYRIDIN- 1 -ONE DERIVATIVES AS SYK KINASE INHIBITORS IRM LLC (BM) 2012-06-06 — — EP claimed
US-20110053897-A1 COMPOUNDS AND COMPOSITIONS AS SYK KINASE INHIBITORS IRM LLC (BM) 2011-03-03 — — US claimed
WO-2011014515-A1 2, 7 -NAPHTHYRIDIN- 1 -ONE DERIVATIVES AS SYK KINASE INHIBITORS IRM LLC (BM) 2011-02-03 — — WO claimed
US-20110053897-A1 COMPOUNDS AND COMPOSITIONS AS SYK KINASE INHIBITORS IRM LLC (BM) 2011-03-03 — — US disclosed
US-20110053897-A1 COMPOUNDS AND COMPOSITIONS AS SYK KINASE INHIBITORS IRM LLC (BM) 2011-03-03 — — US disclosed
US-20110053897-A1 COMPOUNDS AND COMPOSITIONS AS SYK KINASE INHIBITORS IRM LLC (BM) 2011-03-03 — — US disclosed
WO-2011014515-A1 2, 7 -NAPHTHYRIDIN- 1 -ONE DERIVATIVES AS SYK KINASE INHIBITORS IRM LLC (BM) 2011-02-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110053897-A1 COMPOUNDS AND COMPOSITIONS AS SYK KINASE INHIBITORS SYK, BTK, LYN IDH2 2963/4885ZAP70 5/4885FDPS 2703/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.