Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 18/20 | 0.60 |
| ▸ | CA2 | P00918 | 18/20 | 0.60 |
| ▸ | CA7 | P43166 | 8/20 | 0.60 |
| ▸ | CA13 | Q8N1Q1 | 8/20 | 0.60 |
| ▸ | CA12 | O43570 | 7/20 | 0.58 |
| ▸ | CA6 | P23280 | 7/20 | 0.58 |
| ▸ | CA9 | Q16790 | 5/20 | 0.58 |
| ▸ | CA3 | P07451 | 4/20 | 0.56 |
| ▸ | CA4 | P22748 | 4/20 | 0.56 |
| ▸ | CA5A | P35218 | 4/20 | 0.56 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.56 |
| ▸ | CA5B | Q9Y2D0 | 4/20 | 0.56 |
| ▸ | MMP2 | P08253 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11597815 | 0.85 | CA1 (0.62) | CA1CA2CA7CA13CA12 | |
| SCHEMBL11531237 | 0.85 | CA1 (0.62) | CA1CA2CA7CA13CA12 | |
| SCHEMBL10962312 | 0.84 | CA1 (0.60) | CA1CA2CA7CA13CA12 | |
| Hydrochloric Acid SCHEMBL11357213 | 0.84 | CA1 (0.64) | CA1CA2CA7CA13CA12 | |
| SCHEMBL11598119 | 0.84 | CA1 (0.60) | CA1CA2CA7CA13CA12 | |
| SCHEMBL11597761 | 0.84 | CA1 (0.60) | CA1CA2CA7CA13CA12 | |
| SCHEMBL11091668 | 0.81 | CA1 (0.57) | CA1CA2CA7CA13CA12 | |
| SCHEMBL5508135 | 0.81 | CA1 (0.67) | CA1CA2CA7CA13CA12 | |
| SCHEMBL11340163 | 0.81 | CA1 (0.58) | CA1CA2CA7CA13CA12 | |
| SCHEMBL11346061 | 0.81 | CA1 (0.58) | CA1CA2CA7CA13CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4129656-A | Thiazolidine derivatives, salidiuretic compositions and methods of effecting salidiuresis employing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1978-12-12 | — | — | US | disclosed |
| US-4125614-A | DIURETIC | HOECHST AKTIENGESELLSCHAFT (DE) | 1978-11-14 | — | — | US | disclosed |
| US-4061761-A | Thiazolidine derivatives | HOECHST AKTIENGESELLSCHAFT (DT) | 1977-12-06 | — | — | US | disclosed |