Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SCSF1RDRD2FLT1FLT3FLT4HTR1BHTR1DHTR1FKDRKITMETOPRD1OPRK1OPRM1PDGFRAPDGFRBRET
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 4/20 | 0.89 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.41 |
| ▸ | CPT2 | P23786 | 1/20 | 0.33 |
| ▸ | CPT1A | P50416 | 1/20 | 0.33 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LDHA | P00338 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL29817862 | 0.97 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL95331 | 0.97 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL7573233 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL11056334 | 0.94 | CA4 (0.89) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL22797824 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL7651730 | 0.94 | CA4 (0.89) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL7574684 | 0.94 | CA4 (0.94) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL9239581 | 0.94 | CA4 (0.89) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL10524037 | 0.94 | CA4 (0.89) | CA4CTSLCA2SLC22A16CPT2 | |
| Malic Acid SCHEMBL29107242 | 0.94 | CA4 (0.89) | CA4CTSLCA2SLC22A16CPT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4124636-A | CRYSTALLIZATION FROM AQUEOUS SOLUTION OF L-MALIC ACID AND POTASSIUM ION | TANABE SEIYAKU CO., LTD. (JP) | 1978-11-07 | — | — | US | disclosed |