Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 15/20 | 0.71 |
| ▸ | CLK1 | P49759 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8341396 | 0.96 | ESR1 (0.76) | ESR1CLK1DYRK1ADYRK1BESR2 | |
| SCHEMBL8338171 | 0.93 | ESR1 (0.63) | ESR1CLK1DYRK1ADYRK1B | |
| SCHEMBL11600001 | 0.91 | ESR1 (0.67) | ESR1ESR2 | |
| SCHEMBL21260801 | 0.91 | ESR1 (0.78) | ESR1CLK1DYRK1ADYRK1BESR2 | |
| SCHEMBL11600909 | 0.89 | ESR1 (0.58) | ESR1ESR2 | |
| SCHEMBL11598721 | 0.89 | ESR1 (0.56) | ESR1CLK1DYRK1ADYRK1BMEN1 | |
| SCHEMBL21261046 | 0.88 | ESR1 (0.63) | ESR1CLK1DYRK1ADYRK1BESR2 | |
| SCHEMBL21260814 | 0.87 | ESR1 (0.62) | ESR1CLK1DYRK1ADYRK1BESR2 | |
| SCHEMBL21260850 | 0.87 | ESR1 (0.62) | ESR1CLK1DYRK1ADYRK1BESR2 | |
| SCHEMBL21260976 | 0.87 | ESR1 (0.62) | ESR1CLK1DYRK1ADYRK1BESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4075227-A | NONSTEROIDAL | ELI LILLY AND COMPANY (US) | 1978-02-21 | — | — | US | disclosed |