Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12904164 | 1.00 | BRD4 (0.31) | BRD4CREBBP | |
| SCHEMBL1160419 | 1.00 | BRD4 (0.31) | BRD4CREBBP | |
| SCHEMBL1159824 | 0.86 | — | — | |
| SCHEMBL1159822 | 0.86 | — | — | |
| SCHEMBL1159987 | 0.86 | — | — | |
| SCHEMBL12904168 | 0.82 | JAK2 (0.38) | — | |
| SCHEMBL14779518 | 0.80 | BRD4 (0.37) | BRD4CREBBP | |
| SCHEMBL14780031 | 0.80 | BRD4 (0.37) | BRD4CREBBP | |
| SCHEMBL1934179 | 0.78 | — | — | |
| SCHEMBL14780054 | 0.78 | BRD4 (0.33) | BRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2459566-A1 | TRICYCLIC INHIBITORS OF JAK | F. Hoffmann-La Roche AG (CH) | 2012-06-06 | — | — | EP | disclosed |
| WO-2011012540-A1 | TRICYCLIC INHIBITORS OF JAK | F. HOFFMANN-LA ROCHE AG (CH) | 2011-02-03 | — | — | WO | disclosed |