SCHEMBL11601115

SCHEMBL11601115

Oc1ccc(COc2ccc(F)cc2)cc1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 9/20 0.69
APP P05067 3/20 0.69
NR4A2 P43354 1/20 0.66
LMNA P02545 2/20 0.64
CYP1A2 P05177 1/20 0.64
PTGS1 P23219 1/20 0.64
SLC6A2 P23975 1/20 0.64
CYP2C19 P33261 1/20 0.64
PTGS2 P35354 1/20 0.64
SLC6A3 Q01959 1/20 0.64
HIF1A Q16665 1/20 0.64
HDAC6 Q9UBN7 1/20 0.64
PARP10 Q53GL7 1/20 0.64
CA12 O43570 1/20 0.59
CA1 P00915 1/20 0.59
CA2 P00918 1/20 0.59
CA7 P43166 1/20 0.59
CA9 Q16790 1/20 0.59
MAOA P21397 1/20 0.57
RAB9A P51151 2/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3618029 1.00 MAOB (0.69) MAOBAPPNR4A2LMNACYP1A2
SCHEMBL27550091 0.91 MAOB (0.80) MAOBAPPNR4A2PARP10CA12
SCHEMBL11578826 0.89 APP (0.79) APPLMNACYP1A2PTGS1SLC6A2
SCHEMBL5633306 0.89 APP (0.79) APPLMNACYP1A2PTGS1SLC6A2
SCHEMBL713596 0.86 MAOB (0.67) MAOBAPPNR4A2PARP10CA12
SCHEMBL18937890 0.85 MAOB (0.71) MAOBAPPNR4A2PARP10CA12
SCHEMBL10494806 0.83 APP (0.70) APPLMNACYP1A2PTGS1SLC6A2
SCHEMBL22596639 0.83 APP (0.70) APPLMNACYP1A2PTGS1SLC6A2
SCHEMBL5633288 0.83 APP (0.70) APPLMNACYP1A2PTGS1SLC6A2
SCHEMBL21340442 0.82 MAOB (0.69) MAOBAPPNR4A2RAB9ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4072754-A ANTICHOLESTEROL MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) 1978-02-07 US disclosed
US-4039683-A PHENOXYPROPIONIC ACID DERIVATIVES AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) 1977-08-02 US disclosed
US-4031245-A TETRABENAZINE, ANTIDEPRESSANTS A. H. ROBINS COMPANY, INCORPORATED (US) 1977-06-21 US disclosed
US-3978129-A TETRABENAZINE ANTAGONISM A. H. ROBINS COMPANY, INCORPORATED (US) 1976-08-31 US disclosed
US-3968143-A Phenoxypropionic acid derivatives MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) 1976-07-06 US disclosed