Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.94 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.39 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 7/20 | 0.35 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.34 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.34 |
| ▸ | SCN4A | P35499 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.33 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL507542 | 1.00 | CHRM1 (0.94) | CHRM1KCNH2PTGS1SLC6A2SLC6A4 | |
| Pretomanid SCHEMBL14004006 | 0.97 | CHRM1 (1.00) | CHRM1KCNH2PTGS1SLC6A2SLC6A4 | |
| Pretomanid SCHEMBL2983011 | 0.97 | CHRM1 (1.00) | CHRM1KCNH2PTGS1SLC6A2SLC6A4 | |
| SCHEMBL508066 | 0.94 | CHRM1 (0.94) | CHRM1KCNH2PTGS1SLC6A2SLC6A4 | |
| SCHEMBL508124 | 0.92 | CHRM1 (0.90) | CHRM1KCNH2PTGS1SLC6A2SLC6A4 | |
| SCHEMBL508123 | 0.92 | CHRM1 (0.90) | CHRM1KCNH2PTGS1SLC6A2SLC6A4 | |
| SCHEMBL508335 | 0.92 | CHRM1 (0.90) | CHRM1KCNH2PTGS1SLC6A2SLC6A4 | |
| Pretomanid SCHEMBL28576553 | 0.89 | CHRM1 (0.84) | CHRM1KCNH2PTGS1SLC6A2SLC6A4 | |
| Pretomanid SCHEMBL28576555 | 0.88 | CHRM1 (0.82) | CHRM1KCNH2PTGS1SLC6A2SLC6A4 | |
| Tba-354 SCHEMBL508426 | 0.87 | CHRM1 (0.81) | CHRM1KCNH2PTGS1SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2459571-B1 | NITROIMIDAZOOXAZINES AND THEIR USES IN ANTI-TUBERCULAR THERAPY | GLOBAL ALLIANCE FOR TB DRUG DEV (US) | 2015-03-11 | — | — | EP | claimed |
| EP-2459571-A1 | NITROIMIDAZOOXAZINES AND THEIR USES IN ANTI-TUBERCULAR THERAPY | Global Alliance For Tb Drug Development (US) | 2012-06-06 | — | — | EP | claimed |
| WO-2011014774-A1 | NITROIMIDAZOOXAZINES AND THEIR USES IN ANTI-TUBERCULAR THERAPY | GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT (US) | 2011-02-03 | — | — | WO | claimed |