Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.61 |
| ▸ | DRD2 | P14416 | 4/20 | 0.56 |
| ▸ | DRD3 | P35462 | 3/20 | 0.56 |
| ▸ | MCOLN2 | Q8IZK6 | 5/20 | 0.53 |
| ▸ | MCOLN1 | Q9GZU1 | 5/20 | 0.53 |
| ▸ | MCOLN3 | Q8TDD5 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.48 |
| ▸ | HTR3B | O95264 | 1/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HTR3A | P46098 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.48 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11606362 | 1.00 | SLC18A3 (0.61) | SLC18A3DRD2DRD3MCOLN2MCOLN1 | |
| SCHEMBL11606358 | 1.00 | SLC18A3 (0.61) | SLC18A3DRD2DRD3MCOLN2MCOLN1 | |
| SCHEMBL11603611 | 0.92 | SLC18A3 (0.64) | SLC18A3DRD2DRD3MCOLN2MCOLN1 | |
| SCHEMBL11603615 | 0.92 | SLC18A3 (0.64) | SLC18A3DRD2DRD3MCOLN2MCOLN1 | |
| SCHEMBL11603608 | 0.92 | SLC18A3 (0.64) | SLC18A3DRD2DRD3MCOLN2MCOLN1 | |
| SCHEMBL11752871 | 0.89 | SLC18A3 (0.56) | SLC18A3DRD2DRD3MCOLN2MCOLN1 | |
| SCHEMBL11752515 | 0.89 | SLC18A3 (0.56) | SLC18A3DRD2DRD3MCOLN2MCOLN1 | |
| SCHEMBL11752519 | 0.89 | SLC18A3 (0.56) | SLC18A3DRD2DRD3MCOLN2MCOLN1 | |
| SCHEMBL11747670 | 0.89 | SLC18A3 (0.56) | SLC18A3DRD2DRD3MCOLN2MCOLN1 | |
| SCHEMBL11749125 | 0.89 | SLC18A3 (0.56) | SLC18A3DRD2DRD3MCOLN2MCOLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4018773-A | Phenylpiperazinotetrahydronaphthols and derivatives | E. R. SQUIBB & SONS, INC. (US) | 1977-04-19 | — | — | US | claimed |
| US-4081444-A | Phenylpiperazinotetrahydronaphthols and derivatives | E. R. SQUIBB & SONS, INC. (US) | 1978-03-28 | — | — | US | disclosed |
| US-4018773-A | Phenylpiperazinotetrahydronaphthols and derivatives | E. R. SQUIBB & SONS, INC. (US) | 1977-04-19 | — | — | US | disclosed |