Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.49 |
| ▸ | RAB9A | P51151 | 7/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 5/20 | 0.36 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.35 |
| ▸ | CTRC | Q99895 | 1/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11611124 | 0.73 | NPC1 (0.47) | NPC1RAB9ASMN1; SMN2CYP2C19MEN1 | |
| SCHEMBL19280567 | 0.71 | KMT2A (0.67) | NPC1RAB9ACYP2C19MEN1KMT2A | |
| SCHEMBL30626035 | 0.71 | KMT2A (0.67) | NPC1RAB9ACYP2C19MEN1KMT2A | |
| SCHEMBL11613046 | 0.70 | NPC1 (0.43) | NPC1RAB9ASMN1; SMN2CYP2C19MEN1 | |
| SCHEMBL3645053 | 0.68 | F2 (0.54) | F2PRSS2CTRC | |
| SCHEMBL8100186 | 0.68 | F2 (0.59) | F2PRSS2CTRC | |
| SCHEMBL11616709 | 0.67 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2CYP2C19MEN1 | |
| SCHEMBL3644533 | 0.67 | F2 (0.55) | F2PRSS2CTRC | |
| SCHEMBL11613095 | 0.67 | NPC1 (0.41) | NPC1RAB9ASMN1; SMN2CYP2C19MEN1 | |
| SCHEMBL11614849 | 0.67 | NPSR1 (0.49) | NPC1RAB9ACYP2C19MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4117145-A | DIURETIC, HYPOTENSIVE, ANTITHROMBOTIC AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1978-09-26 | — | — | US | disclosed |
| US-4117143-A | USED AS ANTITHROMBOTIC AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1978-09-26 | — | — | US | disclosed |
| US-4113957-A | DIURETIC, SALURETIC, HYPOTENSIVE, ANTITHROMBOTIC | BAYER AKTIENGESELLSCHAFT (DE) | 1978-09-12 | — | — | US | disclosed |