Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 12/20 | 0.71 |
| ▸ | CNR1 | P21554 | 8/20 | 0.71 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.71 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.71 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.71 |
| ▸ | ABHD12 | Q8N2K0 | 2/20 | 0.63 |
| ▸ | ABHD6 | Q9BV23 | 2/20 | 0.63 |
| ▸ | FAAH | O00519 | 1/20 | 0.63 |
| ▸ | LDHA | P00338 | 1/20 | 0.63 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.63 |
| ▸ | GPR183 | P32249 | 1/20 | 0.63 |
| ▸ | DRD3 | P35462 | 1/20 | 0.63 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.63 |
| ▸ | GPR18 | Q14330 | 1/20 | 0.63 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.63 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11787625 | 1.00 | CNR2 (0.71) | CNR2CNR1NR1I2ADORA3SLC6A3 | |
| SCHEMBL11612711 | 1.00 | CNR2 (0.71) | CNR2CNR1NR1I2ADORA3SLC6A3 | |
| SCHEMBL11616464 | 1.00 | CNR2 (0.71) | CNR2CNR1NR1I2ADORA3SLC6A3 | |
| SCHEMBL11444966 | 1.00 | CNR2 (0.71) | CNR2CNR1NR1I2ADORA3SLC6A3 | |
| SCHEMBL11444967 | 1.00 | CNR2 (0.71) | CNR2CNR1NR1I2ADORA3SLC6A3 | |
| SCHEMBL7755404 | 0.99 | CNR2 (0.72) | CNR2CNR1NR1I2ADORA3SLC6A3 | |
| SCHEMBL31545381 | 0.99 | CNR2 (0.72) | CNR2CNR1NR1I2ADORA3SLC6A3 | |
| SCHEMBL11455743 | 0.99 | CNR2 (0.72) | CNR2CNR1NR1I2ADORA3SLC6A3 | |
| SCHEMBL15558108 | 0.99 | CNR2 (0.72) | CNR2CNR1NR1I2ADORA3SLC6A3 | |
| SCHEMBL11541884 | 0.99 | CNR2 (0.72) | CNR2CNR1NR1I2ADORA3SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4088777-A | Hexahydro-dibenzo[b,d]pyran-9-ones as anticonvulsant drugs | ELI LILLY AND COMPANY (US) | 1978-05-09 | — | — | US | disclosed |
| US-4087547-A | Hexahydro-dibenzo[b,d]pyran-9-ones in treatment of glaucoma | ELI LILLY AND COMPANY (US) | 1978-05-02 | — | — | US | disclosed |
| US-4087546-A | Hexahydro-dibenzo[b,d]pyran-9-ones as antiasthmatic drugs | ELI LILLY AND COMPANY (US) | 1978-05-02 | — | — | US | disclosed |
| US-4087545-A | Hexahydro-dibenzo[b,d]pyran-9-ones as antiemetic drugs | ELI LILLY AND COMPANY (US) | 1978-05-02 | — | — | US | disclosed |
| US-4054582-A | Process for converting cis-hexahydrodibenzo[b,d]pyran-9-ones to trans-hexahydrodibenzo[b,d]-pyran-9-ones | ELI LILLY AND COMPANY (US) | 1977-10-18 | — | — | US | disclosed |
| US-3987188-A | Hexahydro-dibenzo[b,d]pyran-9-ones as sedative drugs | ELI LILLY AND COMPANY (US) | 1976-10-19 | — | — | US | disclosed |
| US-3953603-A | Hexahydro-dibenzo[b,d,]pyran-9-ones as psychotropic, particularly anti-depressant drugs | ELI LILLY AND COMPANY (US) | 1976-04-27 | — | — | US | disclosed |
| US-3944673-A | Hexahydro-dibenzo[b,d]pyran-9-ones as analgesic drugs | ELI LILLY AND COMPANY (US) | 1976-03-16 | — | — | US | disclosed |