⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23648014 | 0.88 | — | — | |
| SCHEMBL7740973 | 0.77 | — | — | |
| SCHEMBL23647973 | 0.75 | — | — | |
| SCHEMBL11290406 | 0.71 | — | — | |
| SCHEMBL8015287 | 0.71 | — | — | |
| SCHEMBL831267 | 0.67 | — | — | |
| SCHEMBL834791 | 0.65 | — | — | |
| SCHEMBL834790 | 0.65 | — | — | |
| SCHEMBL910459 | 0.62 | — | — | |
| SCHEMBL13784614 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10077287-B2 | Tubulysin analogs and methods of making and use | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-09-18 | — | — | US | disclosed |
| US-20160130299-A1 | TUBULYSIN ANALOGS AND METHODS OF MAKING AND USE | BRISTOL-MYERS SQUIBB COMPANY | 2016-05-12 | — | — | US | disclosed |
| US-9156850-B2 | Enediyne compounds, conjugates thereof, and uses and methods therefor | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-10-13 | — | — | US | disclosed |
| US-20140193438-A1 | ENEDIYNE COMPOUNDS, CONJUGATES THEREOF, AND USES AND METHODS THEREFOR | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-07-10 | — | — | US | disclosed |
| US-8394922-B2 | Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof | MEDAREX, INC. (US) | 2013-03-12 | — | — | US | disclosed |
| US-8003687-B2 | Esters of compounds in the leptomycin family | KOSAN BIOSCIENCES INCORPORATED (US) | 2011-08-23 | — | — | US | disclosed |
| WO-2011017249-A1 | ANTIPROLIFERATIVE COMPOUNDS, CONJUGATES THEREOF, METHODS THEREFOR, AND USES THEREOF | MEDAREX, INC. (US) | 2011-02-10 | — | — | WO | disclosed |
| US-20110027274-A1 | ANTIPROLIFERATIVE COMPOUNDS, CONJUGATES THEREOF, METHODS THEREFOR, AND USES THEREOF | MEDAREX, INC. (US) | 2011-02-03 | — | — | US | disclosed |