⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7853551 | 0.98 | DAO (0.31) | — | |
| SCHEMBL7853491 | 0.98 | DAO (0.31) | — | |
| SCHEMBL7854041 | 0.98 | DAO (0.31) | — | |
| SCHEMBL7854043 | 0.95 | — | — | |
| SCHEMBL8924457 | 0.68 | — | — | |
| SCHEMBL11554314 | 0.67 | — | — | |
| SCHEMBL7400825 | 0.67 | — | — | |
| SCHEMBL29577475 | 0.66 | EPHX2 (0.34) | — | |
| SCHEMBL7853323 | 0.65 | — | — | |
| SCHEMBL27783997 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 216 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115135655-B | 1H-pyrazolo [4,3-d ] pyrimidine compounds as Toll-like receptor 7 (TLR 7) agonists | 百时美施贵宝公司 | 2024-07-02 | — | — | CN | disclosed |
| US-20240165249-A1 | MODIFIED SELF-IMMOLATING MOIETIES FOR USE IN PRODRUGS AND CONJUGATES AND METHODS OF USING AND MAKING | BRISTOL-MYERS SQUIBB COMPANY | 2024-05-23 | — | — | US | disclosed |
| CN-111201228-B | 6-amino-7, 9-dihydro-8H-purin-8-one derivatives as Toll-like receptor 7 (TLR 7) agonists | 百时美施贵宝公司 | 2024-04-09 | — | — | CN | disclosed |
| CN-111032657-B | 6-amino-7, 9-dihydro-8H-purin-8-one derivatives as immunostimulant Toll-like receptor 7 (TLR 7) agonists | 百时美施贵宝公司 | 2024-03-29 | — | — | CN | disclosed |
| US-11911483-B2 | Modified self-immolating moieties for use in prodrugs and conjugates and methods of using and making | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-02-27 | — | — | US | disclosed |
| CN-111225918-B | Toll-like receptor 7 (TLR 7) agonists with tricyclic moieties, conjugates thereof, methods and uses thereof | 百时美施贵宝公司 | 2024-01-19 | — | — | CN | disclosed |
| US-20230348468-A1 | 1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS | BRISTOL-MYERS SQUIBB COMPANY | 2023-11-02 | — | — | US | disclosed |
| US-20230295346-A1 | PRODRUGGABLE ANTIBODIES, PRODRUGS THEREOF, AND METHODS OF USE AND MAKING | BRISTOL MYERS SQUIBB CO (US) | 2023-09-21 | — | — | US | disclosed |
| US-20230144824-A1 | 1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS | BRISTOL-MYERS SQUIBB COMPANY | 2023-05-11 | — | — | US | disclosed |
| US-20230140430-A1 | 1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS | BRISTOL-MYERS SQUIBB COMPANY | 2023-05-04 | — | — | US | disclosed |
| EP-1794137-A2 | SPECIFIC KINASE INHIBITORS | Kosan Biosciences, Inc. (US) | 2007-06-13 | — | — | EP | disclosed |
| WO-2007033214-A2 | ESTERS OF COMPOUNDS IN THE LEPTOMYCIN FAMILY | KOSAN BIOSCIENCES INCORPORATED (US) | 2007-03-22 | — | — | WO | disclosed |
| WO-2006127252-A1 | MOTILIDE COMPOUNDS | PFIZER, INC. (US) | 2006-11-30 | — | — | WO | disclosed |
| US-20060270616-A1 | Motilide compounds | PFIZER INC. | 2006-11-30 | — | — | US | disclosed |
| US-20060079494-A1 | Specific kinase inhibitors | KOSAN BIOSCIENCES INCORPORATED | 2006-04-13 | — | — | US | disclosed |
| WO-2006036941-A2 | SPECIFIC KINASE INHIBITORS | KOSAN BIOSCIENCES INCORPORATED (US) | 2006-04-06 | — | — | WO | disclosed |
| EP-0719258-B1 | CYCLIC AMIDE DERIVATIVES FOR PROTECTING AGAINST ULTRAVIOLET RAYS | OTSUKA PHARMA CO LTD (JP) | 2001-10-31 | — | — | EP | disclosed |
| US-5786367-A | OXYGEN SCAVENGERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1998-07-28 | — | — | US | disclosed |
| EP-0719258-A1 | CYCLIC AMIDE DERIVATIVES FOR PROTECTING AGAINST ULTRAVIOLET RAYS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-07-03 | — | — | EP | disclosed |
| WO-1996002508-A1 | CYCLIC AMIDE DERIVATIVES FOR PROTECTING AGAINST ULTRAVIOLET RAYS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-02-01 | — | — | WO | disclosed |