Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA3 | P07451 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CA6 | P23280 | 1/20 | 0.33 |
| ▸ | CA5A | P35218 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL563377 | 0.82 | MAPT (0.43) | APEX1BLMMAPTKMT2AMEN1 | |
| SCHEMBL12972556 | 0.79 | CA1 (0.53) | APEX1BLMMAPTKMT2ALMNA | |
| SCHEMBL27280782 | 0.79 | MAPT (0.60) | APEX1BLMMAPTKMT2ALMNA | |
| SCHEMBL24252607 | 0.79 | MAPT (0.60) | APEX1BLMMAPTKMT2ALMNA | |
| SCHEMBL21827346 | 0.79 | MAPT (0.60) | APEX1BLMMAPTKMT2ALMNA | |
| SCHEMBL563865 | 0.78 | BRD4 (0.50) | APEX1BLMMAPTKMT2AMEN1 | |
| SCHEMBL563681 | 0.77 | MAPT (0.39) | APEX1BLMMAPTKMT2AMEN1 | |
| SCHEMBL564518 | 0.77 | MAPT (0.39) | APEX1BLMMAPTKMT2AMEN1 | |
| SCHEMBL563551 | 0.77 | MAPT (0.39) | APEX1BLMMAPTKMT2AMEN1 | |
| SCHEMBL563682 | 0.76 | BRD4 (0.55) | MAPTKMT2ALMNACA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4118396-A | PYRROLIDIN-2-ONES, CNS AGENTS | I.S.F. S.P.A. (IT) | 1978-10-03 | — | — | US | claimed |
| US-4118396-A | PYRROLIDIN-2-ONES, CNS AGENTS | I.S.F. S.P.A. (IT) | 1978-10-03 | — | — | US | disclosed |