Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ENPEP | Q07075 | 5/20 | 0.35 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.35 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.34 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.34 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.34 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.33 |
| ▸ | GABRP | O00591 | 2/20 | 0.33 |
| ▸ | GABRD | O14764 | 2/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.33 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18980805 | 0.78 | MAPT (0.39) | MAPTSLC22A6GABRR1LMNASLC1A3 | |
| SCHEMBL10653694 | 0.78 | MAPT (0.39) | MAPTSLC22A6GABRR1LMNASLC1A3 | |
| SCHEMBL10655250 | 0.78 | MAPT (0.39) | MAPTSLC22A6GABRR1LMNASLC1A3 | |
| SCHEMBL3516265 | 0.78 | SLC22A6 (0.39) | MAPTSLC22A6GABRR1LMNAFFAR3 | |
| SCHEMBL6898498 | 0.76 | SLC22A6 (0.38) | MAPTSLC22A6GABRR1LMNAFFAR3 | |
| SCHEMBL1162361 | 0.74 | SLC22A6 (0.42) | MAPTSLC22A6GABRR1LMNASLC1A3 | |
| SCHEMBL29961107 | 0.74 | SLC22A6 (0.50) | MAPTSLC22A6GABRR1LMNATDP1 | |
| SCHEMBL25133155 | 0.72 | — | — | |
| SCHEMBL9400992 | 0.71 | TDP1 (0.42) | MAPTSLC22A6GABRR1LMNASLC1A3 | |
| SCHEMBL5374127 | 0.71 | SLC22A6 (0.38) | SLC22A6GABRR1LMNASLC1A3SLC1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2499148-A2 | CONFORMATIONALLY CONSTRAINED, FULLY SYNTHETIC MACROCYCLIC COMPOUNDS | Polyphor Ag (CH) | 2012-09-19 | — | — | EP | claimed |
| WO-2011014973-A2 | CONFORMATIONALLY CONSTRAINED, FULLY SYNTHETIC MACROCYCLIC COMPOUNDS | POLYPHOR AG (CH) | 2011-02-10 | — | — | WO | claimed |