Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.60 |
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.56 |
| ▸ | GAA | P10253 | 6/20 | 0.56 |
| ▸ | GLA | P06280 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | HPGD | P15428 | 6/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11625043 | 0.80 | MEN1 (0.56) | KMT2AMEN1POLBKDM4EGAA | |
| SCHEMBL10740535 | 0.80 | KDM4E (0.53) | KMT2AMEN1POLBKDM4EGAA | |
| SCHEMBL11248747 | 0.80 | KDM4E (0.60) | KMT2AMEN1POLBKDM4EGAA | |
| SCHEMBL11623768 | 0.79 | MEN1 (0.55) | KMT2AMEN1POLBKDM4EGAA | |
| SCHEMBL11624395 | 0.79 | MEN1 (0.55) | KMT2AMEN1POLBKDM4EGAA | |
| SCHEMBL11388659 | 0.78 | MEN1 (0.54) | KMT2AMEN1POLBKDM4EGAA | |
| SCHEMBL23295573 | 0.75 | MEN1 (1.00) | KMT2AMEN1POLBKDM4EGAA | |
| SCHEMBL11643359 | 0.74 | KDM4E (0.70) | KMT2AMEN1POLBKDM4EGAA | |
| SCHEMBL11777403 | 0.74 | SMN1; SMN2 (0.54) | POLBKDM4EGAAHPGDMAPT | |
| SCHEMBL10739754 | 0.74 | KDM4E (0.53) | KMT2AMEN1POLBKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4066766-A | 1-Oxo-6-substituted pyrimido [1,2-a]quinoline-2-carboxylic acids and derivatives thereof and their use as antiallergy agents | PFIZER INC. (US) | 1978-01-03 | — | — | US | disclosed |
| US-4031217-A | PYRIMIDINE-QUINOLINE COMPOUNDS | PFIZER INC. (US) | 1977-06-21 | — | — | US | disclosed |
| US-4017625-A | Anti-allergic N-(5-tetrazolyl)-1-oxo-1H-6-alkoxypyrimido-[1,2-a]quinoline-2-carboxamides and intermediates therefor | PFIZER INC. (US) | 1977-04-12 | — | — | US | disclosed |
| US-4014881-A | ANTIULCER AGENTS | PFIZER INC. (US) | 1977-03-29 | — | — | US | disclosed |