SCHEMBL11632437

SCHEMBL11632437

CC(C)(C)c1ccc(CSC(CCc2ccc(Cl)cc2)CCn2ccnc2)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 4/20 0.49
TP53 P04637 4/20 0.49
CYP1A2 P05177 3/20 0.49
CYP2D6 P10635 3/20 0.49
CYP2C9 P11712 3/20 0.49
CYP2C19 P33261 3/20 0.49
TDP1 Q9NUW8 3/20 0.49
ALOX15 P16050 2/20 0.49
NR1I2 O75469 2/20 0.49
NR3C1 P04150 2/20 0.49
ADORA3 P0DMS8 2/20 0.49
ADRA2B P18089 2/20 0.49
CHRM3 P20309 2/20 0.49
AGTR1 P30556 2/20 0.49
OPRK1 P41145 2/20 0.49
SLC6A3 Q01959 2/20 0.49
PDE4D Q08499 2/20 0.49
KCNH2 Q12809 2/20 0.49
TSHR P16473 2/20 0.49
LMNA P02545 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11632269 0.94 CYP3A4 (0.48) CYP3A4TP53CYP1A2CYP2D6CYP2C9
SCHEMBL11632885 0.91 CYP3A4 (0.57) CYP3A4TP53CYP1A2CYP2D6CYP2C9
SCHEMBL11634997 0.85 CYP3A4 (0.55) CYP3A4TP53CYP1A2CYP2D6CYP2C9
SCHEMBL11750298 0.81 CYP3A4 (0.49) CYP3A4TP53CYP1A2CYP2D6CYP2C9
SCHEMBL11754513 0.81 CYP3A4 (0.48) CYP3A4TP53CYP1A2CYP2D6CYP2C9
SCHEMBL11634165 0.80 CYP2C9 (0.53) CYP3A4TP53CYP1A2CYP2D6CYP2C9
SCHEMBL11635141 0.80 CYP1A2 (0.64) CYP3A4TP53CYP1A2CYP2D6CYP2C9
SCHEMBL11758369 0.80 CYP3A4 (0.47) CYP3A4TP53CYP1A2CYP2D6CYP2C9
SCHEMBL11753882 0.80 CYP3A4 (0.47) CYP3A4TP53CYP1A2CYP2D6CYP2C9
SCHEMBL11753245 0.80 CYP3A4 (0.47) CYP3A4TP53CYP1A2CYP2D6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4078071-A FUNGICIDES, BACTERICIDES, ANTIPROTOZOA AGENTS SYNTEX (U.S.A.) INC. (US) 1978-03-07 US disclosed