Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.36 |
| ▸ | SNCA | P37840 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | NQO2 | P16083 | 1/20 | 0.31 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.31 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.30 |
| ▸ | IL1B | P01584 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1163444 | 0.83 | TAAR1 (0.36) | TAAR1SNCACDK2SLC6A4RXFP1 | |
| SCHEMBL1163156 | 0.79 | TAAR1 (0.47) | TAAR1SNCACDK2SLC6A4RXFP1 | |
| SCHEMBL1163064 | 0.77 | TAAR1 (0.48) | TAAR1SNCACDK2RXFP1ADRB2 | |
| SCHEMBL1163544 | 0.77 | TAAR1 (0.38) | TAAR1SLC6A4ADRB2NQO2MTNR1A | |
| SCHEMBL1163327 | 0.73 | TAAR1 (0.50) | TAAR1SLC6A4ADRB2 | |
| SCHEMBL19650679 | 0.73 | TAAR1 (0.40) | TAAR1SNCASLC6A4 | |
| SCHEMBL1163258 | 0.72 | TAAR1 (0.41) | TAAR1SNCASLC6A4ADRB2NQO2 | |
| SCHEMBL1163053 | 0.72 | SMN1; SMN2 (0.37) | SNCASLC6A4ADRB2P2RX7 | |
| SCHEMBL1162971 | 0.72 | HTR1B (0.43) | TAAR1ADRB2NQO2MTNR1AMTNR1B | |
| SCHEMBL1162934 | 0.72 | TAAR1 (0.42) | TAAR1CDK2ADRB2NQO2MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2464227-A1 | COMPOUNDS AND METHODS OF USE THEREOF | Galenea Corporation (US) | 2012-06-20 | — | — | EP | claimed |
| WO-2011019738-A1 | COMPOUNDS AND METHODS OF USE THEREOF | GALENEA CORPORATION (US) | 2011-02-17 | — | — | WO | claimed |
| EP-2464227-A1 | COMPOUNDS AND METHODS OF USE THEREOF | Galenea Corporation (US) | 2012-06-20 | — | — | EP | disclosed |
| WO-2011019738-A1 | COMPOUNDS AND METHODS OF USE THEREOF | GALENEA CORPORATION (US) | 2011-02-17 | — | — | WO | disclosed |