Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 4/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | F7 | P08709 | 1/20 | 0.48 |
| ▸ | F3 | P13726 | 1/20 | 0.48 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.48 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.48 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.48 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.48 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.48 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.48 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyridine SCHEMBL9065525 | 1.00 | NAPRT (0.60) | NAPRTTSHRTDP1F7F3 | |
| Pyridine SCHEMBL27840495 | 0.97 | NAPRT (0.56) | NAPRTTSHRTDP1F7F3 | |
| Pyridine SCHEMBL1070164 | 0.93 | NAPRT (0.60) | NAPRTTSHRTDP1F7F3 | |
| Pyridine SCHEMBL27474886 | 0.90 | NAPRT (0.56) | NAPRTTSHRTDP1F7F3 | |
| Pyridine SCHEMBL27643283 | 0.90 | NAPRT (0.56) | NAPRTTSHRTDP1F7F3 | |
| Pyridine SCHEMBL27461077 | 0.90 | NAPRT (0.56) | NAPRTTSHRTDP1F7F3 | |
| Pyridine SCHEMBL27887446 | 0.90 | NAPRT (0.56) | NAPRTTSHRTDP1F7F3 | |
| Pyridine SCHEMBL27738793 | 0.90 | NAPRT (0.56) | NAPRTTSHRTDP1F7F3 | |
| Pyridine SCHEMBL28762998 | 0.90 | NAPRT (0.56) | NAPRTTSHRTDP1F7F3 | |
| Pyridine SCHEMBL27811338 | 0.90 | NAPRT (0.56) | NAPRTTSHRTDP1F7F3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 118 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1984891-B | Process for the preparation of carboxamide pyridine derivatives useful as intermediates in the synthesis of NK-1 receptor antagonists | HOFFMANN LA ROCHE | 2012-08-08 | — | — | CN | claimed |
| EP-1776342-B1 | PROCESS FOR PREPARING CARBOXAMIDE PYRIDINE DERIVATIVES USED AS INTERMEDIATES IN THE SYNTHESIS OF NK-1 RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2011-03-02 | — | — | EP | claimed |
| US-7384939-B2 | Process for preparation of pyridine derivatives of NK-1 receptor antagonist | ROCHE COLORADO CORPORATION (US) | 2008-06-10 | — | — | US | claimed |
| CN-1984891-A | Process for the preparation of carboxamide pyridine derivatives useful as intermediates in the synthesis of NK-1 receptor antagonists | HOFFMANN LA ROCHE (CH) | 2007-06-20 | — | — | CN | claimed |
| EP-1776342-A1 | PROCESS FOR PREPARING CARBOXAMIDE PYRIDINE DERIVATIVES USED AS INTERMEDIATES IN THE SYNTHESIS OF NK-1 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-04-25 | — | — | EP | claimed |
| CN-1898201-A | Carbamoyl esters that inhibit cholinesterase and release pharmacologically active agents | SENTION INC (US) | 2007-01-17 | — | — | CN | claimed |
| US-20060014959-A1 | Process for preparation of pyridine derivatives of NK-1 receptor antagonist | ROCHE COLORADO CORPORATION (US) | 2006-01-19 | — | — | US | claimed |
| WO-2006002860-A1 | PROCESS FOR PREPARING CARBOXAMIDE PYRIDINE DERIVATIVES USED AS INTERMEDIATES IN THE SYNTHESIS OF NK-1 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-01-12 | — | — | WO | claimed |
| EP-0231837-B1 | PROCESS FOR THE PREPARATION OF WATER SOLUBLE PHTHALOCYANINE DYES | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-08-02 | — | — | EP | claimed |
| EP-0231837-A2 | Process for the preparation of water soluble phthalocyanine dyes | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-08-12 | — | — | EP | claimed |
| JP-52039681-A | — | — | None | — | — | JP | disclosed |
| JP-5213877-A | — | — | None | — | — | JP | disclosed |
| EP-4384165-B1 | MONOACYLGLYCEROL LIPASE MODULATORS FOR USE IN AUTISM SPECTRUM DISORDERS | JANSSEN PHARMACEUTICA NV (BE) | 2025-07-09 | — | — | EP | disclosed |
| WO-2023106278-A1 | AGRICULTURAL CHEMICAL COMPOSITION AND METHOD FOR PRODUCING SAME | 株式会社MMAG | 2023-06-15 | — | — | WO | disclosed |
| US-11447503-B2 | Pyridine carbamates and their use as GLUN2B receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2022-09-20 | — | — | US | disclosed |
| EP-0092384-B1 | IMPROVED PROCESS FOR MAKING THIOBISCARBAMATES | UNION CARBIDE CORPORATION (US) | 1986-12-30 | — | — | EP | disclosed |
| EP-0138002-A2 | Herbicidal agents containing a photosynthesis inhibitor herbicide together with pyridincarboxylic-acid amides | BAYER AG (DE) | 1985-04-24 | — | — | EP | disclosed |
| US-4146642-A | ANTHELMINTICS | MERCK & CO., INC. (US) | 1979-03-27 | — | — | US | disclosed |
| US-4105767-A | ANTHELMINTICS | MERCK & CO., INC. (US) | 1978-08-08 | — | — | US | disclosed |
| JP-S5239681-A | BASICCSUBSTITUTED PYRIDINE CARBONIC ACID AMIDE AND ACID ADDITION PRODUCT PREPARATION METHOD THEREOF AND MEDICAL MIXTURE CONTAINING THESE COMPOUNDS | CIBA GEIGY AG | 1977-03-28 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11447503-B2 | Pyridine carbamates and their use as GLUN2B receptor modulators | GRIN2B, GRIN2A, GRIN1 | NAPRT 479/4885TSHR 379/4885TDP1 3581/4885 |
| US-20060014959-A1 | Process for preparation of pyridine derivatives of NK-1 receptor antagonist | BDKRB1, TACR1, NPSR1 | NAPRT 1531/4885TSHR 169/4885TDP1 3483/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.