Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OTC | P00480 | 1/20 | 0.60 |
| ▸ | DDAH1 | O94760 | 3/20 | 0.46 |
| ▸ | NOS2 | P35228 | 4/20 | 0.44 |
| ▸ | NOS3 | P29474 | 3/20 | 0.44 |
| ▸ | NOS1 | P29475 | 3/20 | 0.44 |
| ▸ | GSR | P00390 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | GLUL | P15104 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GRM8 | O00222 | 1/20 | 0.39 |
| ▸ | GRM6 | O15303 | 1/20 | 0.39 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL11670283 | 1.00 | OTC (0.60) | OTCDDAH1NOS2NOS3NOS1 | |
| Arginine SCHEMBL3784234 | 0.98 | OTC (0.59) | OTCDDAH1NOS2NOS3NOS1 | |
| Arginine SCHEMBL508141 | 0.98 | OTC (0.62) | OTCDDAH1NOS2NOS3NOS1 | |
| Arginine SCHEMBL11738414 | 0.98 | OTC (0.62) | OTCDDAH1NOS2NOS3NOS1 | |
| Arginine SCHEMBL508142 | 0.98 | OTC (0.62) | OTCDDAH1NOS2NOS3NOS1 | |
| Arginine SCHEMBL11738420 | 0.98 | OTC (0.62) | OTCDDAH1NOS2NOS3NOS1 | |
| Arginine SCHEMBL19622767 | 0.97 | OTC (0.60) | OTCDDAH1NOS2NOS3NOS1 | |
| Arginine SCHEMBL29038538 | 0.97 | OTC (0.60) | OTCDDAH1NOS2NOS3NOS1 | |
| Arginine SCHEMBL20531891 | 0.97 | OTC (0.60) | OTCDDAH1NOS2NOS3NOS1 | |
| Arginine SCHEMBL29089653 | 0.97 | OTC (0.60) | OTCDDAH1NOS2NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4064138-A | Amino acid derivatives | GENERAL MILLS, INC. (US) | 1977-12-20 | — | — | US | claimed |
| US-4064138-A | Amino acid derivatives | GENERAL MILLS, INC. (US) | 1977-12-20 | — | — | US | disclosed |