Sugi Predict

Sugi Predict / Compounds / SCHEMBL1167115

SCHEMBL1167115

SCHEMBL1167115

Cc1ccc(C(=O)n2nc(Nc3ccc(OCCN4CCCC4)cc3)nc2N)cc1

nearest known ligand 0.58

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ AXL P30530 10/20 0.58
▸ INSR P06213 2/20 0.58
▸ BACE1 P56817 11/20 0.58
▸ BRD4 O60885 2/20 0.55
▸ JAK1 P23458 2/20 0.55
▸ HDAC1 Q13547 2/20 0.55
▸ JAK2 O60674 1/20 0.55
▸ RET P07949 1/20 0.55
▸ TYK2 P29597 1/20 0.55
▸ FLT3 P36888 1/20 0.55
▸ JAK3 P52333 1/20 0.55
▸ HDAC8 Q9BY41 1/20 0.55
▸ HDAC6 Q9UBN7 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1167464 0.99 BACE1 (0.58) AXLINSRBACE1BRD4JAK1
SCHEMBL1167612 0.93 BACE1 (0.59) AXLINSRBACE1BRD4JAK1
SCHEMBL1166990 0.90 BACE1 (0.58) AXLINSRBACE1BRD4JAK1
SCHEMBL1167423 0.90 AXL (0.56) AXLINSRBACE1BRD4JAK1
SCHEMBL1167724 0.90 BACE1 (0.56) AXLINSRBACE1BRD4JAK1
SCHEMBL1167428 0.90 AXL (0.56) AXLINSRBACE1BRD4JAK1
SCHEMBL1167996 0.90 AXL (0.58) AXLINSRBACE1BRD4JAK1
SCHEMBL1168123 0.90 AXL (0.56) AXLINSRBACE1BRD4JAK1
SCHEMBL1167509 0.90 BACE1 (0.57) AXLINSRBACE1JAK2
SCHEMBL1167165 0.90 AXL (0.69) AXLINSRBACE1FLT3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7884119-B2 protein tyrosine kinase receptor inhibitors such as 3-amino -1-(1H-indol-5-yl)carbonyl-5-[4-2-(pyrrolidin-1-yl)ethoxy]phenylamino]-1H-1,2,4-triazole, used for treating diseases and conditions associated with neovascularization and/or cell proliferation RIGEL PHARMACEUTICALS, INC. (US) 2011-02-08 — — US claimed
US-20070213375-A1 Triazole derivatives useful as Axl inhibitors RIGEL PHARMACEUTICALS, INC. (US) 2007-09-13 — — US claimed
US-8389557-B2 Triazole derivatives useful as Axl inhibitors RIGEL PHARMACEUTICALS, INC. (US) 2013-03-05 — — US disclosed
US-20110082131-A1 TRIAZOLE DERIVATIVES USEFUL AS AXL INHIBITORS RIGEL PHARMACEUTICALS, INC. (US) 2011-04-07 — — US disclosed
US-7884119-B2 protein tyrosine kinase receptor inhibitors such as 3-amino -1-(1H-indol-5-yl)carbonyl-5-[4-2-(pyrrolidin-1-yl)ethoxy]phenylamino]-1H-1,2,4-triazole, used for treating diseases and conditions associated with neovascularization and/or cell proliferation RIGEL PHARMACEUTICALS, INC. (US) 2011-02-08 — — US disclosed
US-20070213375-A1 Triazole derivatives useful as Axl inhibitors RIGEL PHARMACEUTICALS, INC. (US) 2007-09-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110082131-A1 TRIAZOLE DERIVATIVES USEFUL AS AXL INHIBITORS AXL, TYRO3, FLT3 AXL 1/4885INSR 508/4885BACE1 1261/4885
US-20070213375-A1 Triazole derivatives useful as Axl inhibitors AXL, TYRO3, FLT3 AXL 1/4885INSR 291/4885BACE1 2325/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.